Juan Ma

TL;DR: This study has investigated the antidepressant mechanism of arctigenin by conducting in vitro and in vivo studies, and found that proinflammatory cytokines in microglia via high‐mobility group box 1 (HMGB1)/TLR4/NF‐κB and TNF‐α/TNFR1/NF-κB signalling pathways, leading to depression.

TL;DR: It is suggested that imperatorin is an effective inhibitor of HIF-1 and provide new perspectives into the mechanism of its anticancer activity.

TL;DR: The anti-inflammatory effects of artemisinin in TPA-induced skin inflammation in mice were demonstrated and it was proved that art Artemisinin potentiated TNF-α-induced apoptosis.

TL;DR: Investigation of the potential activity of panaxadiol on programmed cell death-ligand 1 (PD-L1) expression and tumour proliferation in human colon cancer cells and the underlying mechanism revealed insights into development of cancer therapeutic through PD-L 1 inhibition.

TL;DR: Results indicate that SERT might treat depression by inhibiting the activation of microglia via the NF-κB signaling pathway and provides a basis for the research and development of antidepressants that act to reduce inflammation and the expression of inflammatory mediators.