J
Juan Ma
Researcher at Yanbian University
Publications - 55
Citations - 1379
Juan Ma is an academic researcher from Yanbian University. The author has contributed to research in topics: NF-κB & IκBα. The author has an hindex of 19, co-authored 50 publications receiving 773 citations.
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Arctigenin protects against depression by inhibiting microglial activation and neuroinflammation via HMGB1/TLR4/NF-κB and TNF-α/TNFR1/NF-κB pathways.
Xiang Xu,Hu-Nan Piao,Fumie Aosai,Xiao-Yu Zeng,Jia-Hui Cheng,Yue-Xian Cui,Jing Li,Juan Ma,Hu-Ri Piao,Xuejun Jin,Lian Xun Piao +10 more
TL;DR: This study has investigated the antidepressant mechanism of arctigenin by conducting in vitro and in vivo studies, and found that proinflammatory cytokines in microglia via high‐mobility group box 1 (HMGB1)/TLR4/NF‐κB and TNF‐α/TNFR1/NF-κB signalling pathways, leading to depression.
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Imperatorin suppresses proliferation and angiogenesis of human colon cancer cell by targeting HIF-1α via the mTOR/p70S6K/4E-BP1 and MAPK pathways.
Chunliu Mi,Juan Ma,Ke Si Wang,Hong Xiang Zuo,Zhe Wang,Ming Yue Li,Lian Xun Piao,Guang Hua Xu,Xuezheng Li,Zhe Shan Quan,Xuejun Jin +10 more
TL;DR: It is suggested that imperatorin is an effective inhibitor of HIF-1 and provide new perspectives into the mechanism of its anticancer activity.
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Artemisinin inhibits inflammatory response via regulating NF-κB and MAPK signaling pathways.
Ke Si Wang,Junbo Li,Zhe Wang,Chunliu Mi,Juan Ma,Lian Xun Piao,Guang Hua Xu,Xuezheng Li,Xuejun Jin +8 more
TL;DR: The anti-inflammatory effects of artemisinin in TPA-induced skin inflammation in mice were demonstrated and it was proved that art Artemisinin potentiated TNF-α-induced apoptosis.
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Panaxadiol inhibits programmed cell death-ligand 1 expression and tumour proliferation via hypoxia-inducible factor (HIF)-1α and STAT3 in human colon cancer cells
Zhe Wang,Ming Yue Li,Zhi Hong Zhang,Hong Xiang Zuo,Jing Ying Wang,Yue Xing,MyongHak Ri,Hong Lan Jin,Cheng Hua Jin,Guang Hua Xu,Lian Xun Piao,Chang Gao Jiang,Juan Ma,Xuejun Jin +13 more
TL;DR: Investigation of the potential activity of panaxadiol on programmed cell death-ligand 1 (PD-L1) expression and tumour proliferation in human colon cancer cells and the underlying mechanism revealed insights into development of cancer therapeutic through PD-L 1 inhibition.
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Sertraline ameliorates inflammation in CUMS mice and inhibits TNF-α-induced inflammation in microglia cells.
Ying Lu,Xiang Xu,Tong Jiang,Lan Jin,Xu-Dong Zhao,Jia-Hui Cheng,Xuejun Jin,Juan Ma,Hu-Nan Piao,Lian Xun Piao +9 more
TL;DR: Results indicate that SERT might treat depression by inhibiting the activation of microglia via the NF-κB signaling pathway and provides a basis for the research and development of antidepressants that act to reduce inflammation and the expression of inflammatory mediators.