J
Judith Machts
Researcher at Otto-von-Guericke University Magdeburg
Publications - 50
Citations - 1201
Judith Machts is an academic researcher from Otto-von-Guericke University Magdeburg. The author has contributed to research in topics: Amyotrophic lateral sclerosis & Cognition. The author has an hindex of 21, co-authored 46 publications receiving 962 citations. Previous affiliations of Judith Machts include Leibniz Institute for Neurobiology & German Center for Neurodegenerative Diseases.
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Journal ArticleDOI
Basal ganglia pathology in ALS is associated with neuropsychological deficits.
Judith Machts,Kristian Loewe,Joern Kaufmann,Sibylle Jakubiczka,Susanne Abdulla,Susanne Petri,Reinhard Dengler,Hans-Jochen Heinze,Stefan Vielhaber,Mircea Ariel Schoenfeld,Peter Bede +10 more
TL;DR: Results suggest that the degree of subcortical gray matter pathology in C9orf72-negative ALS is closely associated with neuropsychological changes, and a preferential vulnerability has been identified within basal ganglia subregions, which connect directly to key cortical sites of ALS pathology.
Journal ArticleDOI
Cortical thinning and its relation to cognition in amyotrophic lateral sclerosis
Christina Schuster,Elisabeth Kasper,Martin Dyrba,Judith Machts,Daniel Bittner,Jörn Kaufmann,Alex J. Mitchell,Reiner Benecke,Stefan J. Teipel,Stefan J. Teipel,Stefan Vielhaber,Stefan Vielhaber,Johannes Prudlo,Johannes Prudlo +13 more
TL;DR: The cognitive status of ALS subjects is associated with different patterns of cortical atrophy, and cognitively impaired ALS patients showed cortical thinning in regions largely overlapping with those found in ALS-FTD, but changes were less widespread.
Journal ArticleDOI
Focal thinning of the motor cortex mirrors clinical features of amyotrophic lateral sclerosis and their phenotypes: a neuroimaging study
Christina Schuster,Elisabeth Kasper,Judith Machts,Daniel Bittner,Jörn Kaufmann,Reiner Benecke,Stefan J. Teipel,Stefan J. Teipel,Stefan Vielhaber,Stefan Vielhaber,Johannes Prudlo,Johannes Prudlo +11 more
TL;DR: According to the analysis, dominant UMN patients demonstrated the most distinct thinning followed by classical ALS patients, and the bulbar subscore of the ALSFRS-R correlated with thinning of the left inferior PMC.
Journal ArticleDOI
Hippocampal degeneration in patients with amyotrophic lateral sclerosis
Susanne Abdulla,Susanne Abdulla,Susanne Abdulla,Judith Machts,Joern Kaufmann,Karina Patrick,Katja Kollewe,Reinhard Dengler,Hans-Jochen Heinze,Hans-Jochen Heinze,Hans-Jochen Heinze,Susanne Petri,Stefan Vielhaber,Stefan Vielhaber,Peter J. Nestor +14 more
TL;DR: Hippocampal volume loss and its correlation with the severity of verbal memory impairment highlight significant hippocampal involvement which can occur as a non-motor deficit in patients with ALS.
Journal ArticleDOI
Peripheral nerve ultrasound in amyotrophic lateral sclerosis phenotypes
Stefanie Schreiber,Stefanie Schreiber,Susanne Abdulla,Susanne Abdulla,Susanne Abdulla,Grazyna Debska-Vielhaber,Judith Machts,Verena Dannhardt-Stieger,Helmut Feistner,Andreas Oldag,Michael Goertler,Susanne Petri,Katja Kollewe,Siegfried Kropf,Frank Schreiber,Hans-Jochen Heinze,Hans-Jochen Heinze,Reinhard Dengler,Peter J. Nestor,Stefan Vielhaber,Stefan Vielhaber +20 more
TL;DR: Ulnar nerve ultrasound in ALS subgroups revealed significant differences in distal CSA values, which suggests it has value as a marker of LMN involvement, and was particularly evident in the UMND and PLS groups.