Judith Murray-Rust

TL;DR: The crystal structure of the murine NGF dimer is reported, which reveals a novel protomer structure consisting of three antiparallel pairs of β strands, together forming a flat surface that provides a model for rational design of analogues of NGF and its relatives and for testing the NGF-receptor recognition determinants critical for signal transduction.

TL;DR: It is shown that loss of DDAH-1 activity leads to accumulation of ADMA and reduction in NO signaling, which causes vascular pathophysiology, including endothelial dysfunction, increased systemic vascular resistance and elevated systemic and pulmonary blood pressure, and it is suggested that DDAh inhibition could be harnessed therapeutically to reduce the vascular collapse associated with sepsis.

TL;DR: The protein kinase C (PKC) family is represented in all eukaryotes and in Homo sapiens comprises the related PKCα through PKCι gene products and form part of the AGC kinase superfamily.

TL;DR: It is shown that Lys-32, Lys-34, and Lys-95 form a positively charged interface involved in binding to p75NGFR, demonstrating a functional dissociation between the two NGF receptors.

TL;DR: It is demonstrated that recombinant D DAH is reversibly inhibited after incubation with NO donors in vitro and mammalian DDAH in cytosolic extracts is also reversibly inhibition by NO donors.