J
Jueng Soo You
Researcher at Konkuk University
Publications - 50
Citations - 2928
Jueng Soo You is an academic researcher from Konkuk University. The author has contributed to research in topics: Epigenetics & DNA methylation. The author has an hindex of 19, co-authored 48 publications receiving 2408 citations. Previous affiliations of Jueng Soo You include Sungkyunkwan University & University of Southern California.
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Journal ArticleDOI
Cancer Genetics and Epigenetics: Two Sides of the Same Coin?
Jueng Soo You,Peter A. Jones +1 more
TL;DR: A recent outcome of whole exome sequencing of thousands of human cancers has been the unexpected discovery of many inactivating mutations in genes that control the epigenome, which contributes to cancer.
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DNA Methylation Screening Identifies Driver Epigenetic Events of Cancer Cell Survival
Daniel D. De Carvalho,Shikhar Sharma,Jueng Soo You,Sheng-Fang Su,Phillippa C. Taberlay,Theresa K. Kelly,Xiaojing Yang,Gangning Liang,Peter A. Jones +8 more
TL;DR: Experimental and bioinformatic approaches showed experimentally that these genes must be silenced by DNA methylation for cancer cell survival, suggesting these are key epigenetic events associated with tumorigenesis.
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DNA methylation and cellular reprogramming
TL;DR: Some aspects of cell fate plasticity and epigenetic alterations, with emphasis on DNA methylation during cellular reprogramming are discussed, to enhance the understanding of stem cell biology and facilitate therapeutic applications.
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Polycomb-Repressed Genes Have Permissive Enhancers that Initiate Reprogramming
Phillippa C. Taberlay,Theresa K. Kelly,Chun-Chi Liu,Chun-Chi Liu,Jueng Soo You,Daniel D. De Carvalho,Tina B. Miranda,Xianghong Jasmine Zhou,Gangning Liang,Peter A. Jones +9 more
TL;DR: Genome-wide, a high percentage of Polycomb targets are associated with putative enhancers in permissive states, suggesting that they may provide a widespread avenue for the initiation of cell-fate reprogramming.
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Alcohol dysregulates miR-148a in hepatocytes through FoxO1, facilitating pyroptosis via TXNIP overexpression.
TL;DR: Alcohol decreases miR-148a expression in hepatocytes through FoxO1, facilitating TXNIP overexpression and NLRP3 inflammasome activation, which induces hepatocyte pyroptosis, attenuating liver injury.