J
Jukka Hartikka
Researcher at University of Miami
Publications - 50
Citations - 4716
Jukka Hartikka is an academic researcher from University of Miami. The author has contributed to research in topics: Cholinergic neuron & Nerve growth factor. The author has an hindex of 30, co-authored 50 publications receiving 4653 citations. Previous affiliations of Jukka Hartikka include University of Southern California & Max Planck Society.
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Function of neurotrophic factors in the adult and aging brain and their possible use in the treatment of neurodegenerative diseases.
TL;DR: This review summarizes the current knowledge of characterized neurotrophic factors, including nerve growth factor (NGF) which serves as paradigmatic example when studying novel molecules and strategies for the eventual development of pharmacological applications of these molecules in the treatment of neurodegenerative diseases.
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Gene Therapy by Intramuscular Injection of Plasmid DNA: Studies on Firefly Luciferase Gene Expression in Mice
Marston Manthorpe,Francine Cornefert-Jensen,Jukka Hartikka,Jiin Felgner,Ann Rundell,Michal Margalith,Varavani Dwarki +6 more
TL;DR: Dose-response and time course analyses of p-CMVint-lux DNA injections showed that maximal luciferase expression was achieved with 25 micrograms of DNA at 7-14 days post-injection, and increasing the injection dose by giving multiple injections over a 10-day period increased expression proportionally to the number of injections.
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Chronic intraventricular injections of nerve growth factor elevate hippocampal choline acetyltransferase activity in adult rats with partial septo-hippocampal lesions.
TL;DR: The lack of effect on AChE strongly suggests that the increases in ChAT activity in hippocampus and septum are due to an elevation of Chat activity within cholinergic neurons surviving the lesion rather than to a promotion of sprouting of Cholinergic fibers.
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Regulation of brain-derived neurotrophic factor and nerve growth factor mRNA in primary cultures of hippocampal neurons and astrocytes
TL;DR: Forskolin enhanced the effects of calcium ionophores and kainic acid on BDNF and NGF mRNA levels and norepinephrine produced a marked elevation of BDNF mRNA in astrocytes, an effect that was further enhanced by glutamate receptor agonists.
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An improved plasmid DNA expression vector for direct injection into skeletal muscle.
Jukka Hartikka,M Sawdey,Cornefert-Jensen F,Michal Margalith,KM Barnhart,Nolasco M,H.L. Vahlsing,J Meek,Magda Marquet,Peter Hobart,Jon Norman,Marston Manthorpe +11 more
TL;DR: VM1255 represents an improved plasmid DNA vector that may be useful for gene therapy applications and contains modifications to the polyadenylation and transcriptional termination sequences, plasmids backbone elements, and the luciferase gene itself each increased lucifer enzyme expression levels.