J
Julia A. O'Hara
Researcher at Dartmouth College
Publications - 88
Citations - 2744
Julia A. O'Hara is an academic researcher from Dartmouth College. The author has contributed to research in topics: Verteporfin & Photodynamic therapy. The author has an hindex of 31, co-authored 88 publications receiving 2663 citations. Previous affiliations of Julia A. O'Hara include Dartmouth–Hitchcock Medical Center.
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Journal ArticleDOI
Carboplatin as a potentiator of radiation therapy.
TL;DR: Improved efficacy resulting from ongoing clinical trials coordinating cisplatin with radiation should support the role for carboplatin as a potentiator of radiation therapy since this second generation complex of platinum also interacts with radiation and larger concentrations of platinum should be attainable in tumors using the new drug.
Journal Article
Insulin increases the sensitivity of tumors to irradiation: involvement of an increase in tumor oxygenation mediated by a nitric oxide-dependent decrease of the tumor cells oxygen consumption
Bénédicte F. Jordan,Vincent Grégoire,Roger Demeure,Pierre Sonveaux,Olivier Feron,Julia A. O'Hara,Valérie P. Vanhulle,Nathalie M. Delzenne,Bernard Gallez +8 more
TL;DR: It is demonstrated by immunoblotting that the NO pathway involves a phosphorylation of endothelial NO synthase and showed a concomitant increase in the cyclic GMP tumor level.
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Spin traps: in vitro toxicity and stability of radical adducts.
Nadeem Khan,Carmen M. Wilmot,Gerald M. Rosen,Eugene Demidenko,Jie Sun,Joy Joseph,Julia A. O'Hara,Balaraman Kalyanaraman,Harold M. Swartz +8 more
TL;DR: The radical adducts of the new spin traps have significantly increased stability as compared to DMPO, indicating that the newspin traps potentially offer increased stability of spinAdducts in functioning cells.
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Estimation of Oxygen Distribution in RIF-1 Tumors by Diffusion Model-Based Interpretation of Pimonidazole Hypoxia and Eppendorf Measurements
TL;DR: Numerical simulations of oxygen diffusion from the capillaries in tumor tissue were used to predict the capillary oxygen supply within and near hypoxic regions of the RIF-1 tumor, and a finite element method to simulate the oxygen distribution from a histology section is presented.
Journal ArticleDOI
Changes in oxygenation of intracranial tumors with carbogen: a BOLD MRI and EPR oximetry study.
Jeff F. Dunn,Jeff F. Dunn,Julia A. O'Hara,Youssef Zaim-Wadghiri,Hao Lei,M. Elizabeth Meyerand,Oleg Y. Grinberg,Huagang Hou,P. Jack Hoopes,Eugene Demidenko,Harold M. Swartz +10 more
TL;DR: To examine, using blood oxygen level dependent (BOLD) MRI and EPR oximetry, the changes in oxygenation of intracranial tumors induced by carbogen breathing.