J
Julia Bertolini
Researcher at Leipzig University
Publications - 14
Citations - 344
Julia Bertolini is an academic researcher from Leipzig University. The author has contributed to research in topics: Head and neck squamous-cell carcinoma & Cancer. The author has an hindex of 9, co-authored 13 publications receiving 287 citations.
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Journal ArticleDOI
The role of HPV RNA transcription, immune response-related gene expression and disruptive TP53 mutations in diagnostic and prognostic profiling of head and neck cancer.
Gunnar Wichmann,Maciej Rosolowski,Knut Krohn,Markus Kreuz,Andreas Boehm,Anett Reiche,Ulrike Scharrer,Dirk Halama,Julia Bertolini,Ulrike Bauer,Dana Holzinger,Michael Pawlita,Jochen Hess,Christoph Engel,Dirk Hasenclever,Markus Scholz,Peter Ahnert,Holger Kirsten,Alexander Hemprich,Christian Wittekind,Olf Herbarth,Friedemann Horn,Andreas Dietz,Markus Loeffler +23 more
TL;DR: It is found that tumors with transcriptionally inactive HPV16 (DNA+ RNA‐) are similar to HPV‐negative (DNA‐) tumors regarding gene expression and frequency of TP53 mutations and that an immune response‐related gene expression cluster is associated with lymph node metastasis, independent of HPV16 status.
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Evaluation of single-cell biomechanics as potential marker for oral squamous cell carcinomas: A pilot study
Janine Runge,T.E. Reichert,Anatol Fritsch,Josef A. Käs,Julia Bertolini,Torsten W. Remmerbach,Torsten W. Remmerbach +6 more
TL;DR: Generally, malignant and benign cells showed significantly different mechanical behavior, and these influences had to be substituted by brush biopsies to minimize confounders in pursuing investigations.
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Therapeutic options for treatment of Merkel cell carcinoma
Kathrin Gessner,Gunnar Wichmann,Andreas Boehm,Anett Reiche,Julia Bertolini,Johannes Brus,Ina Sterker,Stefan Dietzsch,Andreas Dietz +8 more
TL;DR: The different results achieved using cisplatin, docetaxel, and cetuximab led to the conclusion that an individual chemoresponse testing in a predictive short time assay might potentially be a useful diagnostic tool in identifying potentially effective chemotherapy treatments.
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Oral brush biopsy analysis by MALDI-ToF Mass Spectrometry for early cancer diagnosis
Katja Maurer,Klaus Eschrich,Wolfgang Schellenberger,Julia Bertolini,Stefan Rupf,Torsten W. Remmerbach,Torsten W. Remmerbach +6 more
TL;DR: ICPP using MALDI-ToF MS is able to distinguish between healthy and cancerous mucosa and between oral lesions and oral cancer with excellent sensitivity and specificity, which may lead to more accurate early diagnosis of HNSCC.