H
Holger Kirsten
Researcher at Leipzig University
Publications - 133
Citations - 4025
Holger Kirsten is an academic researcher from Leipzig University. The author has contributed to research in topics: Genome-wide association study & Medicine. The author has an hindex of 28, co-authored 116 publications receiving 2620 citations. Previous affiliations of Holger Kirsten include Fraunhofer Society & Translational Centre for Regenerative Medicine.
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Unraveling the polygenic architecture of complex traits using blood eQTL metaanalysis
Urmo Võsa,Annique Claringbould,Harm-Jan Westra,Marc Jan Bonder,Patrick Deelen,Biao Zeng,Holger Kirsten,Ashis Saha,Roman Kreuzhuber,Silva Kasela,Natalia Pervjakova,Alvaes I,Marie-Julie Favé,Mawusse Agbessi,Mark W. Christiansen,Rick Jansen,Ilkka Seppälä,Lin Tong,Alexander Teumer,Katharina Schramm,Gibran Hemani,Joost Verlouw,Hanieh Yaghootkar,Reyhan Sonmez,Andrew A. Brown,Andrew A. Brown,Kukushkina,Anette Kalnapenkis,Sina Rüeger,Eleonora Porcu,Jaanika Kronberg-Guzman,Jarno Kettunen,Joseph E. Powell,Bernett Lee,Futao Zhang,Wibowo Arindrarto,Frank Beutner,Harm Brugge,Dmitreva J,Mahmoud Elansary,Benjamin P. Fairfax,Michel Georges,Bastiaan T. Heijmans,Mika Kähönen,Yungil Kim,Julian C. Knight,Peter Kovacs,Knut Krohn,Shuang Li,Markus Loeffler,Urko M. Marigorta,Hailiang Mei,Yukihide Momozawa,Martina Müller-Nurasyid,Matthias Nauck,Michel G. Nivard,Brenda W.J.H. Penninx,Jonathan K. Pritchard,Olli T. Raitakari,Rotzchke O,Eline Slagboom,Coen D.A. Stehouwer,Michael Stumvoll,Patrick F. Sullivan,Peter A C 't Hoen,Joachim Thiery,Anke Tönjes,van Dongen J,van Iterson M,Jan H. Veldink,Uwe Völker,C Wijmenga,Morris A. Swertz,Anand Kumar Andiappan,Grant W. Montgomery,Samuli Ripatti,Markus Perola,Z. Kutalik,Emmanouil T. Dermitzakis,Sven Bergmann,Timothy M. Frayling,van Meurs J,Holger Prokisch,Habibul Ahsan,Brandon L. Pierce,Terho Lehtimäki,D.I. Boomsma,Bruce M. Psaty,Sina A. Gharib,Philip Awadalla,Lili Milani,Willem H. Ouwehand,Kate Downes,Oliver Stegle,Alexis Battle,Jian Yang,Peter M. Visscher,Markus Scholz,Greg Gibson,Tõnu Esko,Lude Franke +100 more
TL;DR: It is observed that cis-eQTLs can be detected for 88% of the studied genes, but that they have a different genetic architecture compared to disease-associated variants, limiting the ability to use cis- eZTLs to pinpoint causal genes within susceptibility loci.
Journal ArticleDOI
Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression
Urmo Võsa,Annique Claringbould,Annique Claringbould,Harm-Jan Westra,Marc Jan Bonder,Patrick Deelen,Biao Zeng,Holger Kirsten,Ashis Saha,Roman Kreuzhuber,Roman Kreuzhuber,Roman Kreuzhuber,Seyhan Yazar,Harm Brugge,Roy Oelen,Dylan H. de Vries,Monique G. P. van der Wijst,Silva Kasela,Natalia Pervjakova,Isabel Alves,Marie-Julie Favé,Mawusse Agbessi,Mark W. Christiansen,Rick Jansen,Ilkka Seppälä,Lin Tong,Alexander Teumer,Katharina Schramm,Gibran Hemani,Joost Verlouw,Hanieh Yaghootkar,Hanieh Yaghootkar,Hanieh Yaghootkar,Reyhan Sönmez Flitman,Reyhan Sönmez Flitman,Andrew A. Brown,Andrew A. Brown,Viktorija Kukushkina,Anette Kalnapenkis,Sina Rüeger,Eleonora Porcu,Jaanika Kronberg,Johannes Kettunen,Bernett Lee,Futao Zhang,Ting Qi,Jose Alquicira Hernandez,Wibowo Arindrarto,Frank Beutner,Peter A C 't Hoen,Joyce B. J. van Meurs,Jenny van Dongen,Maarten van Iterson,Morris A. Swertz,Julia Dmitrieva,Mahmoud Elansary,Benjamin P. Fairfax,Michel Georges,Bastiaan T. Heijmans,Alex W. Hewitt,Mika Kähönen,Yungil Kim,Yungil Kim,Julian C. Knight,Peter Kovacs,Knut Krohn,Shuang Li,Markus Loeffler,Urko M. Marigorta,Urko M. Marigorta,Hailang Mei,Yukihide Momozawa,Martina Müller-Nurasyid,Matthias Nauck,Michel G. Nivard,Brenda W.J.H. Penninx,Jonathan K. Pritchard,Olli T. Raitakari,Olli T. Raitakari,Olaf Rötzschke,Eline Slagboom,Coen D.A. Stehouwer,Michael Stumvoll,Patrick F. Sullivan,Joachim Thiery,Anke Tönjes,Jan H. Veldink,Uwe Völker,Robert Warmerdam,Cisca Wijmenga,Morris Swertz,Anand Kumar Andiappan,Grant W. Montgomery,Samuli Ripatti,Markus Perola,Zoltán Kutalik,Emmanouil T. Dermitzakis,Emmanouil T. Dermitzakis,Sven Bergmann,Sven Bergmann,Timothy M. Frayling,Holger Prokisch,Habibul Ahsan,Brandon L. Pierce,Terho Lehtimäki,Dorret I. Boomsma,Bruce M. Psaty,Sina A. Gharib,Philip Awadalla,Lili Milani,Willem H. Ouwehand,Willem H. Ouwehand,Willem H. Ouwehand,Kate Downes,Kate Downes,Oliver Stegle,Oliver Stegle,Alexis Battle,Peter M. Visscher,Jian Yang,Jian Yang,Markus Scholz,Joseph E. Powell,Joseph E. Powell,Greg Gibson,Tõnu Esko,Lude Franke +126 more
TL;DR: In this article, the authors performed cis-and trans-expression quantitative trait locus (eQTL) analyses using blood-derived expression from 31,684 individuals through the eQTLGen Consortium.
A catalog of genetic loci associated with kidney function from analyses of a million individuals
Matthias Wuttke,Yong Li,Man Li,Karsten B. Sieber,Mary F. Feitosa,Mathias Gorski,Adrienne Tin,Lihua Wang,Audrey Y. Chu,Anselm Hoppmann,Holger Kirsten,Ayush Giri,Jin-Fang Chai,Gardar Sveinbjornsson,Bamidele O. Tayo,Teresa Nutile,Christian Fuchsberger,Jonathan Marten,Massimiliano Cocca,Sahar Ghasemi,Yizhe Xu,Katrin Horn,Damia Noce,Peter J. van der Most,Sanaz Sedaghat,Zhi Yu,Masato Akiyama,Saima Afaq,Tarunveer S. Ahluwalia,Peter Almgren,Najaf Amin,Johan Ärnlöv,Stephan J. L. Bakker,Nisha Bansal,Daniela Baptista,Sven Bergmann,Mary L. Biggs,Ginevra Biino,Michael Boehnke,Eric Boerwinkle,Mathilde Boissel,Erwin P. Bottinger,Thibaud Boutin,Hermann Brenner,Marco Brumat,Ralph Burkhardt,Adam S. Butterworth,Eric Campana,Archie Campbell,Harry Campbell,Mickaël Canouil,Robert J. Carroll,Eulalia Catamo,John C. Chambers,Miao-Ling Chee,Miao-Li Chee,Xu Chen,Ching-Yu Cheng,Yurong Cheng,Kaare Christensen,Renata Cifkova,Marina Ciullo,Maria Pina Concas,James P. Cook,Josef Coresh,Tanguy Corre,Cinzia Sala,Daniele Cusi,John Danesh,E. Warwick Daw,Martin H. de Borst,Alessandro De Grandi,Renée de Mutsert,Aiko P. J. de Vries,Frauke Degenhardt,Graciela E. Delgado,Ayse Demirkan,Emanuele Di Angelantonio,Katalin Dittrich,Jasmin Divers,Rajkumar Dorajoo,Kai-Uwe Eckardt,Georg Ehret,Paul Elliott,Karlhans Endlich,Michele K. Evans,Janine F. Felix,Valencia Hui Xian Foo,Oscar H. Franco,Andre Franke,Barry I. Freedman,Sandra Freitag-Wolf,Yechiel Friedlander,Philippe Froguel,Ron T. Gansevoort,He Gao,Paolo Gasparini,J. Michael Gaziano,Vilmantas Giedraitis,Christian Gieger,Giorgia Girotto,Franco Giulianini,Martin Gögele,Scott D. Gordon,Daniel F. Gudbjartsson,Vilmundur Gudnason,Toomas Haller,Pavel Hamet,Tamara B. Harris,Catharina A. Hartman,Caroline Hayward,Jacklyn N. Hellwege,Chew-Kiat Heng,Andrew A. Hicks,Edith Hofer,Wei Huang,Nina Hutri-Kähönen,Shih-Jen Hwang,M. Arfan Ikram,Olafur S. Indridason,Erik Ingelsson,Marcus Ising,Vincent W. V. Jaddoe,Johanna Jakobsdottir,Jost B. Jonas,Peter K. Joshi,Navya Shilpa Josyula,Bettina Jung,Mika Kähönen,Yoichiro Kamatani,Candace M. Kammerer,Masahiro Kanai,Mika Kastarinen,Shona M. Kerr,Chiea Chuen Khor,Wieland Kiess,Marcus E. Kleber,Wolfgang Koenig,Jaspal S. Kooner,Antje Körner,Peter Kovacs,Aldi T. Kraja,Alena Krajčoviechová,Holly Kramer,Bernhard K. Krämer,Florian Kronenberg,Michiaki Kubo,Brigitte Kühnel,Mikko Kuokkanen,Johanna Kuusisto,Martina La Bianca,Markku Laakso,Leslie A. Lange,Carl D. Langefeld,Jeannette Lee,Benjamin Lehne,Terho Lehtimäki,Wolfgang Lieb,Su Chi Lim,Lars Lind,Cecilia M. Lindgren,Jun Liu,Jianjun Liu,Markus Loeffler,Ruth J. F. Loos,Susanne Lucae,Mary Ann Lukas,Leo-Pekka Lyytikäinen,Reedik Mägi,Patrik K. E. Magnusson,Anubha Mahajan,Nicholas G. Martin,Jade Martins,Winfried März,Deborah Mascalzoni,Koichi Matsuda,Christa Meisinger,Thomas Meitinger,Olle Melander,Andres Metspalu,Evgenia K. Mikaelsdottir,Yuri Milaneschi,Kozeta Miliku,Pashupati P. Mishra,VA Million Veteran Program,Karen L. Mohlke,Nina Mononen,Grant W. Montgomery,Dennis O. Mook-Kanamori,Josyf C. Mychaleckyj,Girish N. Nadkarni,Mike A. Nalls,Matthias Nauck,Kjell Nikus,Boting Ning,Ilja M. Nolte,Raymond Noordam,Jeffrey R. O'Connell,Michelle L. O'Donoghue,Isleifur Olafsson,Albertine J. Oldehinkel,Marju Orho-Melander,Willem H. Ouwehand,Sandosh Padmanabhan,Nicholette D. Palmer,Runolfur Palsson,Brenda W.J.H. Penninx,Thomas T. Perls,Markus Perola,Mario Pirastu,Nicola Pirastu,Giorgio Pistis,Anna I. Podgornaia,Ozren Polasek,Belen Ponte,David J. Porteous,Tanja Poulain,Peter P. Pramstaller,Michael Preuss,Bram P. Prins,Michael A. Province,Ton J. Rabelink,Laura M. Raffield,Olli T. Raitakari,Dermot F. Reilly,Rainer Rettig,Myriam Rheinberger,Kenneth Rice,Paul M. Ridker,Fernando Rivadeneira,Federica Rizzi,David J. Roberts,Antonietta Robino,Peter Rossing,Igor Rudan,Rico Rueedi,Daniela Ruggiero,Kathleen A. Ryan,Yasaman Saba,Charumathi Sabanayagam,Veikko Salomaa,Erika Salvi,Kai-Uwe Saum,Helena Schmidt,Reinhold Schmidt,Ben Schöttker,Christina-Alexandra Schulz,Nicole Schupf,Christian M. Shaffer,Yuan Shi,Albert V. Smith,Blair H. Smith,Nicole Soranzo,Cassandra N. Spracklen,Konstantin Strauch,Heather M. Stringham,Michael Stumvoll,Per Svensson,Silke Szymczak,E-Shyong Tai,Salman M. Tajuddin,Nicholas Y. Q. Tan,Kent D. Taylor,Andrej Teren,Yih Chung Tham,Joachim Thiery,Chris H. L. Thio,Hauke Thomsen,Gudmar Thorleifsson,Daniela Toniolo,Anke Tönjes,Johanne Tremblay,Ioanna Tzoulaki,André G. Uitterlinden,Simona Vaccargiu,Rob M. van Dam,Pim van der Harst,Cornelia M. van Duijn,Digna R. Velez Edward,Niek Verweij,Suzanne Vogelezang,Uwe Völker,Peter Vollenweider,Gérard Waeber,Melanie Waldenberger,Lars Wallentin,Ya Xing Wang,Chaolong Wang,Dawn M. Waterworth,Wen Bin Wei,Harvey D. White,John Whitfield,Sarah H. Wild,James F. Wilson,Mary K. Wojczynski,Charlene A. Wong,Tien Yin Wong,Liang Xu,Qiong Yang,Masayuki Yasuda,Laura M. Yerges-Armstrong,Weihua Zhang,Alan B. Zonderman,Jerome I. Rotter,Murielle Bochud,Bruce M. Psaty,Veronique Vitart,James G. Wilson,Abbas Dehghan,Afshin Parsa,Daniel I. Chasman,Kevin Ho,Andrew P. Morris,Olivier Devuyst,Shreeram Akilesh,Sarah A. Pendergrass,Xueling Sim,Carsten A. Böger,Yukinori Okada,Todd L. Edwards,Harold Snieder,Kari Stefansson,Adriana M. Hung,Iris M. Heid,Markus Scholz,Alexander Teumer,Anna Köttgen,Cristian Pattaro +327 more
TL;DR: Trans-ancestry meta-analysis of estimated glomerular filtration rate (eGFR) from 1,046,070 individuals identifies 264 associated loci, providing a resource of molecular targets for translational research of chronic kidney disease.
Journal ArticleDOI
Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels
Adrienne Tin,Jonathan Marten,Victoria L. Halperin Kuhns,Yong Li,Matthias Wuttke,Holger Kirsten,Karsten B. Sieber,Chengxiang Qiu,Mathias Gorski,Mathias Gorski,Zhi Yu,Ayush Giri,Ayush Giri,Gardar Sveinbjornsson,Man Li,Audrey Y. Chu,Anselm Hoppmann,Luke J. O’Connor,Bram P. Prins,Teresa Nutile,Damia Noce,Masato Akiyama,Massimiliano Cocca,Sahar Ghasemi,Peter J. van der Most,Katrin Horn,Yizhe Xu,Christian Fuchsberger,Sanaz Sedaghat,Saima Afaq,Saima Afaq,Najaf Amin,Johan Ärnlöv,Johan Ärnlöv,Stephan J. L. Bakker,Nisha Bansal,Daniela Baptista,Sven Bergmann,Sven Bergmann,Sven Bergmann,Mary L. Biggs,Ginevra Biino,Eric Boerwinkle,Erwin P. Bottinger,Thibaud Boutin,Marco Brumat,Ralph Burkhardt,Ralph Burkhardt,Eric Campana,Archie Campbell,Harry Campbell,Robert J. Carroll,Eulalia Catamo,John C. Chambers,Marina Ciullo,Maria Pina Concas,Josef Coresh,Tanguy Corre,Tanguy Corre,Daniele Cusi,Sala Cinzia Felicita,Martin H. de Borst,Alessandro De Grandi,Renée de Mutsert,Aiko P. J. de Vries,Graciela E. Delgado,Ayse Demirkan,Ayse Demirkan,Olivier Devuyst,Katalin Dittrich,Kai-Uwe Eckardt,Kai-Uwe Eckardt,Georg Ehret,Karlhans Endlich,Michele K. Evans,Ron T. Gansevoort,Paolo Gasparini,Vilmantas Giedraitis,Christian Gieger,Giorgia Girotto,Martin Gögele,Scott D. Gordon,Daniel F. Gudbjartsson,Vilmundur Gudnason,Toomas Haller,Pavel Hamet,Tamara B. Harris,Caroline Hayward,Andrew A. Hicks,Edith Hofer,Hilma Holm,Wei Huang,Nina Hutri-Kähönen,Shih-Jen Hwang,M. Arfan Ikram,Raychel M. Lewis,Erik Ingelsson,Johanna Jakobsdottir,Ingileif Jonsdottir,Helgi Jonsson,Peter K. Joshi,Navya Shilpa Josyula,Bettina Jung,Mika Kähönen,Yoichiro Kamatani,Masahiro Kanai,Shona M. Kerr,Wieland Kiess,Marcus E. Kleber,Wolfgang Koenig,Wolfgang Koenig,Jaspal S. Kooner,Antje Körner,Peter Kovacs,Bernhard K. Krämer,Florian Kronenberg,Michiaki Kubo,Brigitte Kühnel,Martina La Bianca,Leslie A. Lange,Benjamin Lehne,Terho Lehtimäki,Jun Liu,Jun Liu,Markus Loeffler,Ruth J. F. Loos,Leo-Pekka Lyytikäinen,Reedik Mägi,Anubha Mahajan,Anubha Mahajan,Nicholas G. Martin,Winfried März,Winfried März,Winfried März,Deborah Mascalzoni,Koichi Matsuda,Christa Meisinger,Thomas Meitinger,Andres Metspalu,Yuri Milaneschi,Christopher J. O'Donnell,Christopher J. O'Donnell,Otis D. Wilson,J. Michael Gaziano,J. Michael Gaziano,Pashupati P. Mishra,Karen L. Mohlke,Nina Mononen,Grant W. Montgomery,Dennis O. Mook-Kanamori,Martina Müller-Nurasyid,Girish N. Nadkarni,Mike A. Nalls,Matthias Nauck,Kjell Nikus,Boting Ning,Ilja M. Nolte,Raymond Noordam,Jeffrey R. O'Connell,Isleifur Olafsson,Sandosh Padmanabhan,Brenda W.J.H. Penninx,Thomas T. Perls,Annette Peters,Mario Pirastu,Nicola Pirastu,Giorgio Pistis,Ozren Polasek,Belen Ponte,David J. Porteous,Tanja Poulain,Michael Preuss,Ton J. Rabelink,Laura M. Raffield,Olli T. Raitakari,Olli T. Raitakari,Rainer Rettig,Myriam Rheinberger,Kenneth Rice,Federica Rizzi,Antonietta Robino,Igor Rudan,Alena Krajčoviechová,Renata Cifkova,Rico Rueedi,Rico Rueedi,Daniela Ruggiero,Kathleen A. Ryan,Yasaman Saba,Erika Salvi,Helena Schmidt,Reinhold Schmidt,Christian M. Shaffer,Albert V. Smith,Blair H. Smith,Cassandra N. Spracklen,Konstantin Strauch,Michael Stumvoll,Patrick Sulem,Salman M. Tajuddin,Andrej Teren,Joachim Thiery,Chris H. L. Thio,Unnur Thorsteinsdottir,Daniela Toniolo,Anke Tönjes,Johanne Tremblay,André G. Uitterlinden,Simona Vaccargiu,Pim van der Harst,Cornelia M. van Duijn,Cornelia M. van Duijn,Cornelia M. van Duijn,Niek Verweij,Uwe Völker,Peter Vollenweider,Gérard Waeber,Melanie Waldenberger,John Whitfield,Sarah H. Wild,James F. Wilson,Qiong Yang,Weihua Zhang,Weihua Zhang,Alan B. Zonderman,Murielle Bochud,James G. Wilson,Sarah A. Pendergrass,Kevin Ho,Afshin Parsa,Afshin Parsa,Peter P. Pramstaller,Bruce M. Psaty,Bruce M. Psaty,Carsten A. Böger,Harold Snieder,Adam S. Butterworth,Yukinori Okada,Todd L. Edwards,Todd L. Edwards,Kari Stefansson,Katalin Susztak,Markus Scholz,Iris M. Heid,Adriana M. Hung,Adriana M. Hung,Alexander Teumer,Cristian Pattaro,Owen M. Woodward,Veronique Vitart,Anna Köttgen,Anna Köttgen +251 more
TL;DR: A trans-ancestry genome-wide association study of serum urate levels identifies 183 loci that improve the prediction of gout in an independent cohort of 334,880 individuals, and implicates the kidney and liver as key target organs and prioritize potential causal genes.
Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences
Richard Karlsson Linnér,Pietro Biroli,Edward Kong,Fleur Meddens,Robbee Wedow,Mark Alan Fontana,Mael Lebreton,Stephen P. Tino,Abdel Abdellaoui,Anke R. Hammerschlag,Michel G. Nivard,Aysu Okbay,Cornelius A. Rietveld,Pascal N. Timshel,Maciej Trzaskowski,Ronald de Vlaming,Christian L. Zund,Yanchun Bao,Laura Buzdugan,Ann H. Caplin,Chia-Yen Chen,Peter Eibich,Pierre Fontanillas,Juan R. González,Peter K. Joshi,Ville Karhunen,Aaron Kleinman,Remy Z. Levin,Christina M. Lill,Gerardus A. Meddens,Gerard Muntané,Sandra Sanchez-Roige,Frank J. A. van Rooij,Erdogan Taskesen,Yang Wu,Futao Zhang,Michelle Agee,Babak Alipanahi,Robert K. Bell,Katarzyna Bryc,Sarah L. Elson,Nicholas A. Furlotte,Karen E. Huber,Nadia K. Litterman,Jennifer C. McCreight,Matthew H. McIntyre,Joanna L. Mountain,Carrie A.M. Northover,Steven J. Pitts,J. Fah Sathirapongsasuti,Olga V. Sazonova,Janie F. Shelton,Suyash Shringarpure,Chao Tian,Joyce Y. Tung,Vladimir Vacic,Catherine H. Wilson,Mawusse Agbessi,Habibul Ahsan,Isabel Alves,Anand Kumar Andiappan,Philip Awadalla,Alexis Battle,Frank Beutner,Marc Jan Bonder,Dorret I. Boomsma,Mark W. Christiansen,Annique Claringbould,Patrick Deelen,Tõnu Esko,Marie-Julie Favé,Lude Franke,Timothy M. Frayling,Sina A. Gharib,Gregory Gibson,Bastiaan T. Heijmans,Gibran Hemani,Rick Jansen,Mika Kähönen,Anette Kalnapenkis,Silva Kasela,Johannes Kettunen,Yungil Kim,Holger Kirsten,Peter Kovacs,Knut Krohn,Jaanika Kronberg-Guzman,Viktorija Kukushkina,Zoltán Kutalik,Bernett Lee,Terho Lehtimäki,Markus Loeffler,Urko M. Marigorta,Andres Metspalu,Lili Milani,Grant W. Montgomery,Martina Mueller-Nurasyid,Matthias Nauck,Brenda W.J.H. Penninx,Markus Perola,Natalia Pervjakova,Brandon L. Pierce,Joseph E. Powell,Holger Prokisch,Bruce M. Psaty,Olli T. Raitakari,Susan M. Ring,Samuli Ripatti,Olaf Rotzchke,Sina Rüeger,Ashis Saha,Markus Scholz,Katharina Schramm,Ilkka Seppälä,Michael Stumvoll,Patrick Sullivan,Peter-Bramt Hoen,Alexander Teumer,Joachim Thiery,Lin Tong,Anke Tönjes,Jenny van Dongen,Joyce B. J. van Meurs,Joost Verlouw,Peter M. Visscher,Uwe Voelker,Urmo Võsa,Harm-Jan Westra,Hanieh Yaghootkar,Jian Yang,Biao Zeng,James J. Lee,Tune H. Pers,Patrick Turley,Guo-Bo Chen,Valur Emilsson,Sven Oskarsson,Joseph K. Pickrell,Kevin Thom,Pascal Timshel,Tarunveer S. Ahluwalia,Jonas Bacelis,Clemens Baumbach,Gyda Bjornsdottir,Johannes H. Brandsma,Maria Pina Concas,Jaime Derringer,Tessel E. Galesloot,Giorgia Girotto,Richa Gupta,Leanne M. Hall,Sarah E. Harris,Edith Hofer,Momoko Horikoshi,Jennifer E. Huffman,Kadri Kaasik,Ioanna P. Kalafati,Augustine Kong,Jari Lahti,Sven J. van der Lee,Christiaan de Leeuw,Penelope A. Lind,Karl-Oskar Lindgren,Tian Liu,Massimo Mangino,Jonathan Marten,Evelin Mihailov,Michael B. Miller,Peter J. van der Most,Christopher Oldmeadow,Antony Payton,Wouter J. Peyrot,Yong Qian,Rico Rueedi,Erika Salvi,Boerge Schmidt,Katharina E. Schraut,Jianxin Shi,Albert V. Smith,Raymond A. Poot,Beate St Pourcain,Gudmar Thorleifsson,Niek Verweij,Dragana Vuckovic,Juergen Wellmann,Jingyun Yang,Wei Zhao,Zhihong Zhu,Behrooz Z. Alizadeh,Najaf Amin,Andrew Bakshi,Sebastian E. Baumeister,Ginevra Biino,Klaus Bønnelykke,Patricia A. Boyle,Harry Campbell,Francesco P. Cappuccio,Gail Davies,Jan-Emmanuel De Neve,Panos Deloukas,Ilja Demuth,Jun Ding,Lewin Eisele,Niina Eklund,David M. Evans,Jessica D. Faul,Mary F. Feitosa,Andreas J. Forstner,Ilaria Gandin,Bjarni Gunnarsson,Bjarni V. Halldorsson,Tamara B. Harris,Andrew Heath,Lynne J. Hocking,Elizabeth G. Holliday,Georg Homuth,Michael A. Horan,Jouke-Jan Hottenga,Philip L. De Jager,Astanand Jugessur,Marika Kaakinen,Stavroula Kanoni,Liisa Keltigangas-Jarvinen,Lambertus A. Kiemeney,Ivana Kolcic,Seppo Koskinen,Aldi T. Kraja,Martin Kroh,Antti Latvala,Lenore J. Launer,Maël Lebreton,Douglas F. Levinson,Paul Lichtenstein,Peter Lichtner,David C. Liewald,Anu Loukola,Pamela A. F. Madden,Reedik Mägi,Tomi Mäki-Opas,Riccardo E. Marioni,Pedro Marques-Vidal,George McMahon,Christa Meisinger,Thomas Meitinger,Y. Milaneschi,Ronny Myhre,Christopher P. Nelson,Dale R. Nyholt,William E R Ollier,Aarno Palotie,Lavinia Paternoster,Nancy L. Pedersen,K. Petrovic,David J. Porteous,Katri Räikkönen,S M Ring,Antonietta Robino,Olga Rostapshova,Igor Rudan,Aldo Rustichini,Veikko Salomaa,Alan R. Sanders,Antti-Pekka Sarin,Helena Schmidt,Rodney J. Scott,Blair H. Smith,Jennifer A. Smith,Jan A. Staessen,Elisabeth Steinhagen-Thiessen,Konstantin Strauch,Antonio Terracciano,Martin D. Tobin,Sheila Ulivi,Simona Vaccargiu,Lydia Quaye,Cristina Venturini,Anna A. E. Vinkhuyzen,Henry Voelzke,Judith M. Vonk,Diego Vozzi,Johannes Waage,Erin B. Ware,Gonneke Willemsen,John Attia,David A. Bennett,Klaus Berger,Lars Bertram,Hans Bisgaard,Ingrid B. Borecki,Ute Bültmann,Christopher F. Chabris,Francesco Cucca,Daniele Cusi,J. Deary,George Dedoussis,Cornelia M. van Duijn,Johan G. Eriksson,Barbara Franke,Paolo Gasparini,Pablo V. Gejman,Christian Gieger,Hans-Joergen Grabe,Jacob Gratten,Vilmundur Gudnason,Pim van der Harst,Caroline Hayward,David A. Hinds,Wolfgang Hoffmann,Elina Hyppönen,William G. Iacono,Bo Jacobsson,Marjo-Riitta Järvelin,Karl-Heinz Jöckel,Jaakko Kaprio,Sharon L.R. Kardia,Steven F. Lehrer,Patrik K. E. Magnusson,Nicholas G. Martin,Matt McGue,Neil Pendleton,Nicola Pirastu,Mario Pirastu,Ozren Polasek,Danielle Posthuma,Christine Power,Michael A. Province,Nilesh J. Samani,David Schlessinger,Reinhold E. Schmidt,Thorkild I. A. Sørensen,Tim D. Spector,Kari Stefansson,Unnur Thorsteinsdottir,Roy Thurik,Nicholas J. Timpson,Henning Tiemeier,André G. Uitterlinden,Veronique Vitart,Peter Vollenweider,David R. Weir,James F. Wilson,Alan F. Wright,Dalton Conley,Robert F. Krueger,George Davey Smith,David Laibson,Sarah E. Medland,Magnus Johannesson,Philipp Koellinger,David Cesarini,Daniel J. Benjamin,Adam Auton,Jason D. Boardman,David W. Clark,Andrew Conlin,Conor C. Dolan,Urs Fischbacher,Patrick J. F. Groenen,Kathleen Mullan Harris,Gregor Hasler,Albert Hofman,Mohammad Arfan Ikram,Sonia Jain,Robert Karlsson,Ronald C. Kessler,Maarten Kooyman,James MacKillop,Minna Männikkö,Carlos Morcillo-Suarez,Matthew B. McQueen,Klaus M. Schmidt,Melissa C. Smart,Matthias Sutter,Jon White,Harriet de Wit,Ernst Fehr,Meena Kumari,David Laibson,Michelle N. Meyer,Arcadi Navarro,Abraham A. Palmer,Daniel Schunk,Murray B. Stein,Rauli Svento,Paul R. H. J. Timmers,Robert J. Ursano,Gert G. Wagner,Jonathan P. Beauchamp +387 more
TL;DR: A genetic study identifies hundreds of loci associated with risk tolerance and risky behaviors, finds evidence of substantial shared genetic influences across these phenotypes, and implicates genes involved in neurotransmission.