J
Julia Christina Kasper
Researcher at Ludwig Maximilian University of Munich
Publications - 13
Citations - 1074
Julia Christina Kasper is an academic researcher from Ludwig Maximilian University of Munich. The author has contributed to research in topics: Particle size & Particle. The author has an hindex of 11, co-authored 12 publications receiving 935 citations.
Papers
More filters
Journal ArticleDOI
The freezing step in lyophilization: physico-chemical fundamentals, freezing methods and consequences on process performance and quality attributes of biopharmaceuticals.
TL;DR: To get a more comprehensive understanding of the processes that occur during freezing, the physico-chemical fundamentals of freezing are first summarized and the available techniques that can be used to manipulate or directly control the freezing process in lyophilization are reviewed.
Journal ArticleDOI
Structural properties of monoclonal antibody aggregates induced by freeze-thawing and thermal stress.
TL;DR: The complementary methods used in this study revealed that heating and freeze-thawing induced aggregates differ significantly in their physico-chemical characteristics.
Journal ArticleDOI
Recent advances and further challenges in lyophilization.
TL;DR: The dogma of "never lyophilize above the glass transition temperature" is argued, and recent insights into novel stabilization concepts are provided.
Journal ArticleDOI
Comparison of four different particle sizing methods for siRNA polyplex characterization.
Christina Troiber,Julia Christina Kasper,Silvia Milani,Max Scheible,Irene Martin,Frank Schaubhut,Sarah Küchler,Joachim O. Rädler,Friedrich C. Simmel,Wolfgang Friess,Ernst Wagner +10 more
TL;DR: Four different analytical methods were evaluated for their suitability to analyze the characteristics of homogeneous and heterogeneous siRNA polyplexes: dynamic light scattering (DLS), atomic force microscopy (AFM), nanoparticle trafficking analysis (NTA), and fluorescence correlation spectroscopy (FCS).
Journal ArticleDOI
Development of a lyophilized plasmid/LPEI polyplex formulation with long-term stability--A step closer from promising technology to application.
TL;DR: Polyplexes formulated with lactosucrose or hydroxypropylbetadex/sucrose showed high transfection efficiencies and cellular metabolic activities and the current standard limits for particulate contamination for small volume parenterals were met for all formulations.