Julia E. Babensee

TL;DR: The inflammatory response to the biomaterial component and immune response towards transplanted cells are described and examples of devices appropriately integrated as assessed morphologically with the host for various applications including bone, nerve, and skin regeneration are illustrated.

TL;DR: The characteristic properties of growth factors are described to provide a biological basis for their use in tissue engineered devices and a review of experimental evidence illustrates examples of growth factor delivery from devices such as micropaticles, scaffolds, and encapsulated cells, for theirUse in the application of musculoskeletal tissue, neural tissue, and hepatic tissue.

TL;DR: Genetic deficiencies demonstrate that both L FA-1 and Mac-1 contribute to adhesion of neutrophils to endothelial cells and ICAM-1, but adhesion through LFA-1 overshadows the contribution from Mac- 1.

TL;DR: The interconnection between innate and adaptive immunity, the comparative and contrasting phenotypes and roles of Mϕs and DCs in immunity, their responses to biomaterials and the strategies to modulate their phenotype for applications in tissue engineering and vaccine delivery are discussed.

TL;DR: A differential effect of the biomaterial on which iDCs were cultured was observed as far as the extent of induced DC maturation, which is a novel biocompatibility selection and design criteria for biomaterials to be used in combination products in which immune consequences are potential complications or outcomes.