Julia Liebing

TL;DR: It is demonstrated how human stem cells and transcriptome analysis can be combined for mechanistic grouping and prediction of toxicants and extension to mechanisms beyond HDACi would allow prediction of human developmental toxicity hazard of unknown compounds with the UKN1 test system.

TL;DR: To quantitatively describe disturbed development on a genome-wide basis, the concept based on the indices Dp and Di offers the possibility to quantitatively express the propensity of test compounds to interfere with normal development.

TL;DR: Results confirmed that ToCP has a unique mode of action on glutamate receptors that is not observed with the metabolite CBDP and the other symmetric TCP isomers, and is the most potent TCP isomer with respect to structural and functional neurotoxicity in vitro.

TL;DR: In this paper , the authors identify appropriate description standards and quality criteria for the special use of engineered nanomaterials (ENMs) in nanosafety research, and propose a minimum information table (MIT) to describe the minimum information to be provided along with experimental results on effects of ENMs in the biological context.

TL;DR: In this article , the authors identify appropriate description standards and quality criteria for the special use of engineered nanomaterials (ENMs) in nanosafety research, and propose a minimum information table (MIT) to describe the minimum information to be provided along with experimental results on effects of ENMs in the biological context.