N
Nils Bluethgen
Researcher at Humboldt University of Berlin
Publications - 4
Citations - 63
Nils Bluethgen is an academic researcher from Humboldt University of Berlin. The author has contributed to research in topics: Copy number analysis & Developmental toxicity. The author has an hindex of 2, co-authored 4 publications receiving 44 citations. Previous affiliations of Nils Bluethgen include Charité.
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Journal ArticleDOI
Definition of transcriptome-based indices for quantitative characterization of chemically disturbed stem cell development: introduction of the STOP-Tox ukn and STOP-Tox ukk tests
Vaibhav Shinde,Lisa Hoelting,Sureshkumar Perumal Srinivasan,Johannes Meisig,Johannes Meisig,Kesavan Meganathan,Smita Jagtap,Marianna Grinberg,Julia Liebing,Nils Bluethgen,Nils Bluethgen,Jörg Rahnenführer,Eugen Rempel,Regina Stoeber,Stefan Schildknecht,Sunniva Förster,Patricio Godoy,Christoph van Thriel,John Antonydas Gaspar,Jürgen Hescheler,Tanja Waldmann,Jan G. Hengstler,Marcel Leist,Agapios Sachinidis +23 more
TL;DR: To quantitatively describe disturbed development on a genome-wide basis, the concept based on the indices Dp and Di offers the possibility to quantitatively express the propensity of test compounds to interfere with normal development.
Journal ArticleDOI
Reflection of neuroblastoma intratumor heterogeneity in the new OHC‐NB1 disease model
Theresa M Thole,Joern Toedling,Annika Sprüssel,Sebastian Pfeil,Larissa Savelyeva,David Capper,Clemens Messerschmidt,Dieter Beule,Stefanie Groeneveld-Krentz,Cornelia Eckert,Guido Gambara,Anton G. Henssen,Sabine Finkler,Johannes H. Schulte,Anja Sieber,Anja Sieber,Nils Bluethgen,Nils Bluethgen,Christian R A Regenbrecht,Annette Künkele,Marco Lodrini,Angelika Eggert,Hedwig E. Deubzer +22 more
TL;DR: The set of OHC‐NB1 models represents 43% of somatic SNVs and 23% of the cellularity in the originating metastasis with varying clonal compositions, indicating that heterogeneity is partially preserved in the model system.
Posted ContentDOI
An Integrative Genetic, Epigenetic and Proteomic Characterization of Pancreatic Neuroendocrine Neoplasms (PanNENs) defines Distinct Molecular Features of α- and β-cell like Subgroups
Tincy Simon,Soulafa Mamlouk,Soulafa Mamlouk,Pamela Riemer,Felix Bormann,Bertram Klinger,Andrea Menne,Andrea Menne,Daniel Teichmann,Kerstin Wanke-Möhr,Kerstin Wanke-Möhr,Manuela Pacyna-Gengelbach,Slim Khouja,Dido Lenze,David Capper,David Capper,Felix Ruoff,Markus F. Templin,Ulf Leser,Katharina Detjen,Florian Rossner,Johannes Haybaeck,Johannes Haybaeck,Markus Morkel,Nils Bluethgen,Nils Bluethgen,David Horst,Marianne Pavel,Christine Sers,Christine Sers +29 more
TL;DR: Multi-omic analyses on 59 tumors with varying grades were performed, combining mutational profiling with epigenetic analysis and targeted proteomics, providing further insights into the potential mechanisms behind PanNEN heterogeneity.
Posted ContentDOI
Maintaining and escaping feedback control in hierarchically organised tissue: a case study of the intestinal epithelium
TL;DR: In this article, a mathematical model of intestinal epithelium population dynamics is presented based on the current mechanistic understanding of the underlying biological processes, and conditions for stability and identify mechanisms that may lead to loss of homoeostasis.