R
Regina Stöber
Researcher at Technical University of Dortmund
Publications - 23
Citations - 1846
Regina Stöber is an academic researcher from Technical University of Dortmund. The author has contributed to research in topics: Toxicogenomics & Stem cell. The author has an hindex of 12, co-authored 22 publications receiving 1616 citations. Previous affiliations of Regina Stöber include Leibniz Institute for Neurobiology.
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Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.
Patricio Godoy,Nicola J. Hewitt,Ute Albrecht,Melvin E. Andersen,Nariman Ansari,Sudin Bhattacharya,Johannes G. Bode,Jennifer Bolleyn,Christoph Borner,J Böttger,Albert Braeuning,Robert A. Budinsky,Britta Burkhardt,Neil R. Cameron,Giovanni Camussi,Chong Su Cho,Yun Jaie Choi,J. Craig Rowlands,Uta Dahmen,Georg Damm,Olaf Dirsch,María Teresa Donato,Jian Dong,Steven Dooley,Dirk Drasdo,Dirk Drasdo,Dirk Drasdo,Rowena Eakins,Karine Sá Ferreira,Valentina Fonsato,Joanna Fraczek,Rolf Gebhardt,Andrew Gibson,Matthias Glanemann,Christopher E. Goldring,María José Gómez-Lechón,Geny M. M. Groothuis,Lena Gustavsson,Christelle Guyot,David Hallifax,Seddik Hammad,Adam S. Hayward,Dieter Häussinger,Claus Hellerbrand,Philip Hewitt,Stefan Hoehme,Hermann-Georg Holzhütter,J. Brian Houston,Jens Hrach,Kiyomi Ito,Hartmut Jaeschke,Verena Keitel,Jens M. Kelm,B. Kevin Park,Claus Kordes,Gerd A. Kullak-Ublick,Edward L. LeCluyse,Peng Lu,Jennifer Luebke-Wheeler,Anna Lutz,Daniel J. Maltman,Madlen Matz-Soja,Patrick D. McMullen,Irmgard Merfort,Simon Messner,Christoph Meyer,Jessica Mwinyi,Dean J. Naisbitt,Andreas K. Nussler,Peter Olinga,Francesco Pampaloni,Jingbo Pi,Linda J. Pluta,Stefan Przyborski,Anup Ramachandran,Vera Rogiers,Cliff Rowe,Celine Schelcher,Kathrin Schmich,Michael Schwarz,Bijay Singh,Ernst H. K. Stelzer,Bruno Stieger,Regina Stöber,Yuichi Sugiyama,Ciro Tetta,Wolfgang E. Thasler,Tamara Vanhaecke,Mathieu Vinken,Thomas S. Weiss,Agata Widera,Courtney G. Woods,Jinghai James Xu,Kathy Yarborough,Jan G. Hengstler +94 more
TL;DR: This review encompasses the most important advances in liver functions and hepatotoxicity and analyzes which mechanisms can be studied in vitro and how closely hepatoma, stem cell and iPS cell–derived hepatocyte-like-cells resemble real hepatocytes.
Journal ArticleDOI
Gene networks and transcription factor motifs defining the differentiation of stem cells into hepatocyte-like cells
Patricio Godoy,Patricio Godoy,Wolfgang Schmidt-Heck,Karthick Natarajan,Baltasar Lucendo-Villarin,Dagmara Szkolnicka,Annika Asplund,Petter Björquist,Agata Widera,Regina Stöber,G Campos,Seddik Hammad,Agapios Sachinidis,Umesh Chaudhari,Georg Damm,Thomas S. Weiss,Andreas K. Nussler,Jane Synnergren,Karolina Edlund,Barbara Küppers-Munther,David C. Hay,Jan G. Hengstler +21 more
TL;DR: In this article, the authors performed a transcriptomic study with HLC derived from human embryonic and induced stem cells (ESC, hiPSC) from three different laboratories and identified gene networks representing successful and failed hepatocyte differentiation.
Journal ArticleDOI
Toxicogenomics directory of chemically exposed human hepatocytes.
Marianna Grinberg,Regina Stöber,Karolina Edlund,Eugen Rempel,Patricio Godoy,Raymond Reif,Agata Widera,Katrin Madjar,Wolfgang Schmidt-Heck,Rosemarie Marchan,Agapios Sachinidis,Dimitry Spitkovsky,Jürgen Hescheler,Helena Carmo,Marcelo Dutra Arbo,Bob van de Water,Steven Wink,Mathieu Vinken,Vera Rogiers,Sylvia Escher,Barry Hardy,Dragana Mitic,Glenn J. Myatt,Tanja Waldmann,Adil Mardinoglu,Georg Damm,Daniel Seehofer,Andreas K. Nussler,Thomas S. Weiss,Axel Oberemm,Alfons Lampen,Mirjam M. Schaap,Mirjam Luijten,Harry van Steeg,Wolfgang E. Thasler,Jos C. S. Kleinjans,Rob H. Stierum,Marcel Leist,Jörg Rahnenführer,Jan G. Hengstler +39 more
TL;DR: The introduced toxicotranscriptomics directory offers a basis for a rationale choice of candidate genes for biomarker evaluation studies and represents an easy to use source of background information on chemically influenced genes.
Journal ArticleDOI
Gene network activity in cultivated primary hepatocytes is highly similar to diseased mammalian liver tissue.
Patricio Godoy,Agata Widera,Wolfgang Schmidt-Heck,G Campos,Christoph Meyer,Cristina Cadenas,Raymond Reif,Regina Stöber,Seddik Hammad,Seddik Hammad,Seddik Hammad,Larissa Pütter,Kathrin Gianmoena,Rosemarie Marchan,Ahmed Ghallab,Ahmed Ghallab,Karolina Edlund,Andreas K. Nussler,Wolfgang E. Thasler,Georg Damm,Daniel Seehofer,Thomas S. Weiss,Olaf Dirsch,Uta Dahmen,Rolf Gebhardt,Umesh Chaudhari,Kesavan Meganathan,Agapios Sachinidis,Jens M. Kelm,Ute Hofmann,René P. Zahedi,Reinhard Guthke,Nils Blüthgen,Steven Dooley,Jan G. Hengstler +34 more
TL;DR: It is shown that gene regulatory network alterations of cultivated hepatocytes resemble those of inflammatory liver diseases and should therefore be considered and exploited as disease models.
Journal ArticleDOI
A transcriptome-based classifier to identify developmental toxicants by stem cell testing : design, validation and optimization for histone deacetylase inhibitors
Eugen Rempel,Eugen Rempel,Lisa Hoelting,Tanja Waldmann,Nina V. Balmer,Stefan Schildknecht,Marianna Grinberg,John Antonydas Gaspar,Vaibhav Shinde,Regina Stöber,Rosemarie Marchan,Christoph van Thriel,Julia Liebing,Johannes Meisig,Johannes Meisig,Nils Blüthgen,Nils Blüthgen,Agapios Sachinidis,Jörg Rahnenführer,Jan G. Hengstler,Marcel Leist +20 more
TL;DR: It is demonstrated how human stem cells and transcriptome analysis can be combined for mechanistic grouping and prediction of toxicants and extension to mechanisms beyond HDACi would allow prediction of human developmental toxicity hazard of unknown compounds with the UKN1 test system.