J
Jan G. Hengstler
Researcher at Technical University of Dortmund
Publications - 641
Citations - 27118
Jan G. Hengstler is an academic researcher from Technical University of Dortmund. The author has contributed to research in topics: Medicine & Cancer. The author has an hindex of 76, co-authored 573 publications receiving 23821 citations. Previous affiliations of Jan G. Hengstler include University of Mainz & Leibniz Association.
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Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.
Patricio Godoy,Nicola J. Hewitt,Ute Albrecht,Melvin E. Andersen,Nariman Ansari,Sudin Bhattacharya,Johannes G. Bode,Jennifer Bolleyn,Christoph Borner,J Böttger,Albert Braeuning,Robert A. Budinsky,Britta Burkhardt,Neil R. Cameron,Giovanni Camussi,Chong Su Cho,Yun Jaie Choi,J. Craig Rowlands,Uta Dahmen,Georg Damm,Olaf Dirsch,María Teresa Donato,Jian Dong,Steven Dooley,Dirk Drasdo,Dirk Drasdo,Dirk Drasdo,Rowena Eakins,Karine Sá Ferreira,Valentina Fonsato,Joanna Fraczek,Rolf Gebhardt,Andrew Gibson,Matthias Glanemann,Christopher E. Goldring,María José Gómez-Lechón,Geny M. M. Groothuis,Lena Gustavsson,Christelle Guyot,David Hallifax,Seddik Hammad,Adam S. Hayward,Dieter Häussinger,Claus Hellerbrand,Philip Hewitt,Stefan Hoehme,Hermann-Georg Holzhütter,J. Brian Houston,Jens Hrach,Kiyomi Ito,Hartmut Jaeschke,Verena Keitel,Jens M. Kelm,B. Kevin Park,Claus Kordes,Gerd A. Kullak-Ublick,Edward L. LeCluyse,Peng Lu,Jennifer Luebke-Wheeler,Anna Lutz,Daniel J. Maltman,Madlen Matz-Soja,Patrick D. McMullen,Irmgard Merfort,Simon Messner,Christoph Meyer,Jessica Mwinyi,Dean J. Naisbitt,Andreas K. Nussler,Peter Olinga,Francesco Pampaloni,Jingbo Pi,Linda J. Pluta,Stefan Przyborski,Anup Ramachandran,Vera Rogiers,Cliff Rowe,Celine Schelcher,Kathrin Schmich,Michael Schwarz,Bijay Singh,Ernst H. K. Stelzer,Bruno Stieger,Regina Stöber,Yuichi Sugiyama,Ciro Tetta,Wolfgang E. Thasler,Tamara Vanhaecke,Mathieu Vinken,Thomas S. Weiss,Agata Widera,Courtney G. Woods,Jinghai James Xu,Kathy Yarborough,Jan G. Hengstler +94 more
TL;DR: This review encompasses the most important advances in liver functions and hepatotoxicity and analyzes which mechanisms can be studied in vitro and how closely hepatoma, stem cell and iPS cell–derived hepatocyte-like-cells resemble real hepatocytes.
Journal ArticleDOI
The humoral immune system has a key prognostic impact in node-negative breast cancer.
Marcus Schmidt,D Böhm,Christian von Törne,Eric Steiner,Alexander Puhl,Henryk Pilch,Hans-Anton Lehr,Jan G. Hengstler,Heinz Kölbl,Mathias Gehrmann +9 more
TL;DR: It is shown in three cohorts of untreated, node-negative breast cancer patients that the humoral immune system plays a pivotal role in metastasis-free survival of carcinomas of the breast.
Journal ArticleDOI
Primary Hepatocytes: Current Understanding of the Regulation of Metabolic Enzymes and Transporter Proteins, and Pharmaceutical Practice for the Use of Hepatocytes in Metabolism, Enzyme Induction, Transporter, Clearance, and Hepatotoxicity Studies
Nicola J. Hewitt,Maria Jose Gomez Lechon,J. Brian Houston,David Hallifax,Hayley S. Brown,Patrick Maurel,Patrick Maurel,J. Gerry Kenna,Lena Gustavsson,Christina Lohmann,Christian Skonberg,André Guillouzo,Gregor Tuschl,Albert P. Li,Edward L. LeCluyse,Geny M. M. Groothuis,Jan G. Hengstler +16 more
TL;DR: This review brings you up-to-date with the hepatocyte research on in vitro–in vivo correlations of metabolism and clearance, the function and regulation of hepatic transporters and models used to elucidate their role in drug clearance, mechanisms and examples of idiosyncratic and intrinsic hepatotoxicity.
Journal ArticleDOI
A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci
Nathaniel Rothman,Montserrat Garcia-Closas,Nilanjan Chatterjee,Núria Malats,Xifeng Wu,Jonine D. Figueroa,Francisco X. Real,David Van Den Berg,Giuseppe Matullo,Dalsu Baris,Michael J. Thun,Lambertus A. Kiemeney,Paolo Vineis,Immaculata De Vivo,Demetrius Albanes,Mark P. Purdue,Thorunn Rafnar,Michelle A.T. Hildebrandt,Anne E. Kiltie,Olivier Cussenot,Klaus Golka,Rajesh Kumar,Jack A. Taylor,Jose I. Mayordomo,Kevin B. Jacobs,Manolis Kogevinas,Amy Hutchinson,Zhaoming Wang,Yi-Ping Fu,Ludmila Prokunina-Olsson,Laurie Burdett,Meredith Yeager,William Wheeler,Adonina Tardón,Consol Serra,Alfredo Carrato,Reina García-Closas,Josep Lloreta,Alison Johnson,Molly Schwenn,Margaret R. Karagas,Alan R. Schned,Gerald L. Andriole,Robert L. Grubb,Amanda Black,Eric J. Jacobs,W. Ryan Diver,Susan M. Gapstur,Stephanie J. Weinstein,Jarmo Virtamo,Victoria K. Cortessis,Manuela Gago-Dominguez,Malcolm C. Pike,Malcolm C. Pike,Mariana C. Stern,Jian-Min Yuan,David J. Hunter,Monica McGrath,Colin P.N. Dinney,Bogdan Czerniak,Meng Chen,Hushan Yang,Sita H. Vermeulen,Katja K.H. Aben,J. Alfred Witjes,Remco R. R. Makkinje,Patrick Sulem,Søren Besenbacher,Kari Stefansson,Kari Stefansson,Elio Riboli,Paul Brennan,Salvatore Panico,Carmen Navarro,Naomi E. Allen,H. Bas Bueno-de-Mesquita,Dimitrios Trichopoulos,Dimitrios Trichopoulos,Neil E. Caporaso,Maria Teresa Landi,Federico Canzian,Börje Ljungberg,Anne Tjønneland,Françoise Clavel-Chapelon,D T Bishop,Mark Teo,Margaret A. Knowles,Simonetta Guarrera,Silvia Polidoro,Fulvio Ricceri,Carlotta Sacerdote,Alessandra Allione,Geraldine Cancel-Tassin,Silvia Selinski,Jan G. Hengstler,Holger Dietrich,Tony Fletcher,Peter Rudnai,Eugen Gurzau,Kvetoslava Koppova,Sophia C.E. Bolick,Ashley C. Godfrey,Zongli Xu,José I Sanz-Velez,Maria D. Garcia-Prats,Manuel Sanchez,Gabriel Valdivia,Stefano Porru,Simone Benhamou,Simone Benhamou,Robert N. Hoover,Joseph F. Fraumeni,Debra T. Silverman,Stephen J. Chanock +113 more
TL;DR: Two new regions associated with bladder cancer on chromosomes 22q13.1, 19q12 and 2q37.1 are identified and previous candidate associations for the GSTM1 deletion and a tag SNP for NAT2 acetylation status are validated, and interactions with smoking in both regions are found.
Journal ArticleDOI
Molecular Modes of Action of Artesunate in Tumor Cell Lines
Thomas Efferth,Axel Sauerbrey,Armin Olbrich,Erich Gebhart,Pia Rauch,H. Oliver Weber,Jan G. Hengstler,Marc-Eric Halatsch,Manfred Volm,Kenneth D. Tew,Douglas D. Ross,Jens Oliver Funk +11 more
TL;DR: A profound cytotoxic action of the antimalarial, artesunate (ART), was identified against 55 cancer cell lines of the U.S. National Cancer Institute (NCI) and 3 of the 12 genes were used to prove a causative relationship.