Rosemarie Marchan

TL;DR: The evidence that Mrps contribute to the regulation of cellular GSH levels and the thiol-redox state, and thus to the many biochemical processes that are influenced by this tripeptide is summarized.

TL;DR: The history of the AOP concept and its most prominent strengths are discussed, including the advantages of a formalized approach, the systematic collection of weight of evidence, the linkage of mechanisms to apical end points, the examination of the plausibility of epidemiological data, the identification of critical knowledge gaps and the design of mechanistic test methods.

TL;DR: Because transport is a key step in GSH homeostasis and is intimately linked to its biological functions, GSH export proteins are likely to modulate essential cellular functions.

TL;DR: IGKC was consistently associated with metastasis-free survival across different molecular subtypes in node-negative breast cancer and predicted response to anthracycline-based neoadjuvant chemotherapy and was prognostic in NSCLC and colorectal cancer.

TL;DR: The ESNATS assay battery allows classification of human DNT/RT toxicants on the basis of their transcriptome profiles and a relatively large ‘common response’ to VPA and MeHg could be distinguished from ‘compound-specific’ responses.