J
Julia Tischler
Researcher at Wellcome Trust/Cancer Research UK Gurdon Institute
Publications - 21
Citations - 3011
Julia Tischler is an academic researcher from Wellcome Trust/Cancer Research UK Gurdon Institute. The author has contributed to research in topics: Gene & Embryonic stem cell. The author has an hindex of 15, co-authored 18 publications receiving 2805 citations. Previous affiliations of Julia Tischler include University of Vienna & Medical University of Vienna.
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Journal ArticleDOI
Essential function of histone deacetylase 1 in proliferation control and CDK inhibitor repression
Gerda Lagger,Dónal O'Carroll,Martina Rembold,Harald Khier,Julia Tischler,Georg Weitzer,Bernd Schuettengruber,Christoph Hauser,Reinhard Brunmeir,Thomas Jenuwein,Christian Seiser +10 more
TL;DR: This study provides the first evidence that a histone deacetylase is essential for unrestricted cell proliferation by repressing the expression of selective cell cycle inhibitors.
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Systematic mapping of genetic interactions in Caenorhabditis elegans identifies common modifiers of diverse signaling pathways.
Ben Lehner,Ben Lehner,Ben Lehner,Catriona Crombie,Julia Tischler,Angelo Fortunato,Angelo Fortunato,Angelo Fortunato,Andrew G. Fraser +8 more
TL;DR: It is proposed that these genes function as general buffers of genetic variation and that these hub genes may act as modifier genes in multiple, mechanistically unrelated genetic diseases in humans.
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Dynamic heterogeneity and DNA methylation in embryonic stem cells.
Zakary S. Singer,John Yong,Julia Tischler,Jamie A. Hackett,Alphan Altinok,M. Azim Surani,Long Cai,Michael B. Elowitz +7 more
TL;DR: It is found that DNA methylation plays a key role in maintaining these metastable states and the “2i” signaling pathway inhibitors modulate both types of variation.
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Negative and positive regulation of gene expression by mouse histone deacetylase 1.
Gordin Zupkovitz,Julia Tischler,Markus Posch,Iwona Sadzak,Katrin Ramsauer,Gerda Egger,Reinhard Grausenburger,Norbert Schweifer,Susanna Chiocca,Thomas Decker,Christian Seiser +10 more
TL;DR: This study reveals a regulatory cross talk between HDAC1 and HDAC2 and a novel function forHDAC1 as a transcriptional coactivator and a new set of genes found to require HDAC activity and recruitment of HDac1 for their transcriptional activation.
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The tumor suppressor p53 and histone deacetylase 1 are antagonistic regulators of the cyclin-dependent kinase inhibitor p21/WAF1/CIP1 gene.
Gerda Lagger,Angelika Doetzlhofer,Bernd Schuettengruber,Eva Haidweger,Elisabeth Simboeck,Julia Tischler,Susanna Chiocca,Guntram Suske,Hans Rotheneder,Erhard Wintersberger,Christian Seiser +10 more
TL;DR: The findings show that the deacetylase HDAC1 acts as an antagonist of the tumor suppressor p53 in the regulation of the cyclin-dependent kinase inhibitor p21 and provide a basis for understanding the function of histone deacetyase inhibitors as antitumor drugs.