J
Juliana E Toller-Kawahisa
Researcher at University of São Paulo
Publications - 25
Citations - 1718
Juliana E Toller-Kawahisa is an academic researcher from University of São Paulo. The author has contributed to research in topics: Medicine & Inflammation. The author has an hindex of 9, co-authored 16 publications receiving 648 citations. Previous affiliations of Juliana E Toller-Kawahisa include University of London & Queen Mary University of London.
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Journal ArticleDOI
SARS-CoV-2-triggered neutrophil extracellular traps mediate COVID-19 pathology.
Flávio P. Veras,Marjorie Cornejo Pontelli,Camila Meirelles de Souza Silva,Juliana E Toller-Kawahisa,Mikhael de Lima,Daniele C. Nascimento,Ayda Henriques Schneider,Diego B. Caetite,Lucas Alves Tavares,Isadora Marques Paiva,Roberta Ribeiro Costa Rosales,David F. Colón,Ronaldo B. Martins,Italo A. Castro,Glaucia M. Almeida,Maria Isabel Fernandes Lopes,Maira N. Benatti,Letícia Pastorelli Bonjorno,Marcela C Giannini,Rodrigo Luppino-Assad,Sérgio C. L. Almeida,Fernando Crivelenti Vilar,Rodrigo de Carvalho Santana,Valdes Roberto Bollela,Maria Auxiliadora-Martins,Marcos C. Borges,Carlos Henrique Miranda,Antonio Pazin-Filho,Luis Lamberti Pinto da Silva,Larissa D. Cunha,Dario S. Zamboni,Felipe Dal-Pizzol,Luiz O. Leiria,Li Siyuan,Sabrina Setembre Batah,Alexandre Todorovic Fabro,Thais Mauad,Marisa Dolhnikoff,Amaro Nunes Duarte-Neto,Paulo Hilário Nascimento Saldiva,Thiago M. Cunha,José C. Alves-Filho,Eurico Arruda,Paulo Louzada-Junior,Renê Donizeti Ribeiro de Oliveira,Fernando Q. Cunha +45 more
TL;DR: It is described that SARS-CoV-2 triggers the release of ACE2-depended neutrophil extracellular traps (NETs) that mediate lung pathology, supporting the use of NETs inhibitors for COVID-19 treatment.
Journal ArticleDOI
Inflammasomes are activated in response to SARS-CoV-2 infection and are associated with COVID-19 severity in patients.
Tamara S Rodrigues,Keyla Santos Guedes de Sá,Adriene Y. Ishimoto,Amanda Becerra,Samuel L. Oliveira,Letícia Yamawaka de Almeida,Augusto V. Gonçalves,Debora B. Perucello,Warrison A. Andrade,Ricardo M. C. Castro,Flávio P. Veras,Juliana E Toller-Kawahisa,Daniele C. Nascimento,Mikhael Haruo Fernandes de Lima,Camila Meirelles de Souza Silva,Diego B. Caetite,Ronaldo B. Martins,Italo A. Castro,Marjorie Cornejo Pontelli,Fábio Cury de Barros,Fábio Cury de Barros,Natalia B. do Amaral,Marcela C Giannini,Letícia Pastorelli Bonjorno,Maria Isabel Fernandes Lopes,Rodrigo de Carvalho Santana,Fernando Crivelenti Vilar,Maria Auxiliadora-Martins,Rodrigo Luppino-Assad,Sérgio C. L. Almeida,Fabiola Reis de Oliveira,Sabrina Setembre Batah,Li Siyuan,Maira N. Benatti,Thiago M. Cunha,José C. Alves-Filho,Fernando Q. Cunha,Larissa D. Cunha,Fabiani Gai Frantz,Tiana Kohlsdorf,Alexandre Todorovic Fabro,Eurico Arruda,Renê Donizeti Ribeiro de Oliveira,Paulo Louzada-Junior,Dario S. Zamboni +44 more
TL;DR: This work shows that inflammasomes are activated in response to SARS-CoV-2 infection in vitro and in COVID-19 patients, contributing to the exacerbated inflammatory response, impacting disease progression and clinical outcome.
Journal ArticleDOI
Annexin A1 drives macrophage skewing to accelerate muscle regeneration through AMPK activation
Simon McArthur,Gaëtan Juban,Thomas Gobbetti,Thibaut Desgeorges,Marine Theret,Julien Gondin,Juliana E Toller-Kawahisa,Juliana E Toller-Kawahisa,Chris P. M. Reutelingsperger,Bénédicte Chazaud,Mauro Perretti,Rémi Mounier +11 more
TL;DR: Using a model of skeletal muscle injury and repair, annexin A1 (AnxA1) is identified as the extracellular trigger of macrophage skewing toward a pro-reparative phenotype, leading to macrophages skewing, dampening of inflammation, and regeneration of muscle fibers.
Journal ArticleDOI
PKM2 promotes Th17 cell differentiation and autoimmune inflammation by fine-tuning STAT3 activation
Luis Eduardo Alves Damasceno,Douglas Silva Prado,Flávio P. Veras,Miriam M. Fonseca,Juliana E Toller-Kawahisa,Marcos Henrique Rosa,Gabriel Azevedo Publio,Timna Varela Martins,Fernando Silva Ramalho,Ari Waisman,Fernando Q. Cunha,Thiago M. Cunha,José C. Alves-Filho +12 more
TL;DR: It is reported that PKM2, a glycolytic enzyme, plays a nonmetabolic role in mediating Th17 cell differentiation and autoimmune neuroinflammation by fine-tuning STAT3 activation.
Journal ArticleDOI
Neutrophil Extracellular Traps Effectively Control Acute Chikungunya Virus Infection.
Carlos Hiroji Hiroki,Juliana E Toller-Kawahisa,Marcílio Jorge Fumagalli,David F. Colón,Luiz Tadeu Moraes Figueiredo,Bendito A. L. D. Fonseca,Rafael F. O. França,Fernando Q. Cunha +7 more
TL;DR: These findings characterize NETosis as a contributing natural process to control Chikungunya virus acute infection, presenting an antiviral effect that helps to control systemic virus levels.