S
Sérgio C. L. Almeida
Researcher at University of São Paulo
Publications - 14
Citations - 1843
Sérgio C. L. Almeida is an academic researcher from University of São Paulo. The author has contributed to research in topics: Arthritis & Inflammation. The author has an hindex of 8, co-authored 13 publications receiving 932 citations.
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Journal ArticleDOI
SARS-CoV-2-triggered neutrophil extracellular traps mediate COVID-19 pathology.
Flávio P. Veras,Marjorie Cornejo Pontelli,Camila Meirelles de Souza Silva,Juliana E Toller-Kawahisa,Mikhael de Lima,Daniele C. Nascimento,Ayda Henriques Schneider,Diego B. Caetite,Lucas Alves Tavares,Isadora Marques Paiva,Roberta Ribeiro Costa Rosales,David F. Colón,Ronaldo B. Martins,Italo A. Castro,Glaucia M. Almeida,Maria Isabel Fernandes Lopes,Maira N. Benatti,Letícia Pastorelli Bonjorno,Marcela C Giannini,Rodrigo Luppino-Assad,Sérgio C. L. Almeida,Fernando Crivelenti Vilar,Rodrigo de Carvalho Santana,Valdes Roberto Bollela,Maria Auxiliadora-Martins,Marcos C. Borges,Carlos Henrique Miranda,Antonio Pazin-Filho,Luis Lamberti Pinto da Silva,Larissa D. Cunha,Dario S. Zamboni,Felipe Dal-Pizzol,Luiz O. Leiria,Li Siyuan,Sabrina Setembre Batah,Alexandre Todorovic Fabro,Thais Mauad,Marisa Dolhnikoff,Amaro Nunes Duarte-Neto,Paulo Hilário Nascimento Saldiva,Thiago M. Cunha,José C. Alves-Filho,Eurico Arruda,Paulo Louzada-Junior,Renê Donizeti Ribeiro de Oliveira,Fernando Q. Cunha +45 more
TL;DR: It is described that SARS-CoV-2 triggers the release of ACE2-depended neutrophil extracellular traps (NETs) that mediate lung pathology, supporting the use of NETs inhibitors for COVID-19 treatment.
Journal ArticleDOI
Inflammasomes are activated in response to SARS-CoV-2 infection and are associated with COVID-19 severity in patients.
Tamara S Rodrigues,Keyla Santos Guedes de Sá,Adriene Y. Ishimoto,Amanda Becerra,Samuel L. Oliveira,Letícia Yamawaka de Almeida,Augusto V. Gonçalves,Debora B. Perucello,Warrison A. Andrade,Ricardo M. C. Castro,Flávio P. Veras,Juliana E Toller-Kawahisa,Daniele C. Nascimento,Mikhael Haruo Fernandes de Lima,Camila Meirelles de Souza Silva,Diego B. Caetite,Ronaldo B. Martins,Italo A. Castro,Marjorie Cornejo Pontelli,Fábio Cury de Barros,Fábio Cury de Barros,Natalia B. do Amaral,Marcela C Giannini,Letícia Pastorelli Bonjorno,Maria Isabel Fernandes Lopes,Rodrigo de Carvalho Santana,Fernando Crivelenti Vilar,Maria Auxiliadora-Martins,Rodrigo Luppino-Assad,Sérgio C. L. Almeida,Fabiola Reis de Oliveira,Sabrina Setembre Batah,Li Siyuan,Maira N. Benatti,Thiago M. Cunha,José C. Alves-Filho,Fernando Q. Cunha,Larissa D. Cunha,Fabiani Gai Frantz,Tiana Kohlsdorf,Alexandre Todorovic Fabro,Eurico Arruda,Renê Donizeti Ribeiro de Oliveira,Paulo Louzada-Junior,Dario S. Zamboni +44 more
TL;DR: This work shows that inflammasomes are activated in response to SARS-CoV-2 infection in vitro and in COVID-19 patients, contributing to the exacerbated inflammatory response, impacting disease progression and clinical outcome.
Journal ArticleDOI
IL-33 induces neutrophil migration in rheumatoid arthritis and is a target of anti-TNF therapy
Waldiceu A. Verri,Fabricio O. Souto,Silvio M. Vieira,Sérgio C. L. Almeida,Sandra Y. Fukada,Damo Xu,José C. Alves-Filho,Thiago M. Cunha,Ana Tereza Gomes Guerrero,Rafaela B Mattos-Guimaraes,Fabiola Reis Oliveira,Mauro M. Teixeira,João Santana da Silva,Iain B. McInnes,Sérgio H. Ferreira,Paulo Louzada-Junior,Foo Y. Liew,Fernando Q. Cunha +17 more
TL;DR: In this article, the effect of IL-33R on neutrophil migration in rheumatoid arthritis was investigated in mice with mBSA-immunized knee joint.
Journal ArticleDOI
Beneficial effects of colchicine for moderate to severe COVID-19: a randomised, double-blinded, placebo-controlled clinical trial.
Maria Isabel Lopes,Letícia Pastorelli Bonjorno,Marcela C Giannini,Natalia B. do Amaral,Pamella Indira Da Silva Oliveira Menezes,Saulo Musse Dib,Samara Libich Gusmão Gigante,Maira N. Benatti,Uebe C Rezek,Laerte L Emrich-Filho,Betania A A Sousa,Sérgio C. L. Almeida,Rodrigo Luppino Assad,Flávio P. Veras,Ayda Henriques Schneider,Tamara S Rodrigues,Luiz O. Leiria,Larissa D. Cunha,José C. Alves-Filho,Thiago M. Cunha,Eurico Arruda,Carlos Henrique Miranda,Antonio Pazin-Filho,Maria Auxiliadora-Martins,Marcos C. Borges,Benedito Antonio Lopes da Fonseca,Valdes Roberto Bollela,Cristina Marta Del-Ben,Fernando Q. Cunha,Dario S. Zamboni,Rodrigo de Carvalho Santana,Fernando Crivelenti Vilar,Paulo Louzada-Junior,Renê Donizeti Ribeiro de Oliveira +33 more
TL;DR: In this article, a randomized, double-blinded, placebo-controlled clinical trial of colchicine for the treatment of moderate to severe COVID-19, with 75 patients allocated 1:1 from 11 April to 30 August 2020, was presented.
Journal ArticleDOI
Low expression of CD39 on regulatory T cells as a biomarker for resistance to methotrexate therapy in rheumatoid arthritis
Raphael S. Peres,Foo Y. Liew,Foo Y. Liew,Jhimmy Talbot,Vanessa Carregaro,Renê Donizeti Ribeiro de Oliveira,Sérgio C. L. Almeida,Rafael F. O. França,Paula B. Donate,Larissa G. Pinto,Flávia Isaura de Santi Ferreira,Diego L. Costa,Daniel P. Demarque,Dayana Rubio Gouvea,Norberto Peporine Lopes,Regina Helena Costa Queiroz,João Santana da Silva,Florêncio Figueiredo,José C. Alves-Filho,Thiago M. Cunha,S H Ferreira,Paulo Louzada-Junior,Fernando Q. Cunha +22 more
TL;DR: Methotrexate unresponsiveness in RA is associated with low expression of CD39 on Tregs and the decreased suppressive activity of these cells through reduced ADO production, providing hitherto unrecognized mechanism of immune regulation in RA and on mode of action of MTX.