C
Carlos Henrique Miranda
Researcher at University of São Paulo
Publications - 143
Citations - 7963
Carlos Henrique Miranda is an academic researcher from University of São Paulo. The author has contributed to research in topics: Medicine & Germplasm. The author has an hindex of 35, co-authored 136 publications receiving 5997 citations. Previous affiliations of Carlos Henrique Miranda include Université de Montréal & Institut national de la recherche agronomique.
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Journal ArticleDOI
Single-Dose Gene-Replacement Therapy for Spinal Muscular Atrophy
Jerry R. Mendell,Samiah Al-Zaidy,Richard Shell,W. Dave Arnold,Louise R. Rodino-Klapac,Thomas W. Prior,Linda Lowes,Lindsay N. Alfano,K. Berry,Kathleen Church,John T. Kissel,Sukumar Nagendran,James L’Italien,Douglas M. Sproule,Courtney Wells,Jessica A. Cardenas,Marjet D. Heitzer,Allan Arman Kaspar,Sarah Corcoran,Lyndsey Braun,Shibi Likhite,Carlos Henrique Miranda,Kathrin Meyer,K.D. Foust,Arthur H.M. Burghes,Brian K. Kaspar +25 more
TL;DR: In patients with SMA1, a single intravenous infusion of adenoviral vector containing DNA coding for SMN resulted in longer survival, superior achievement of motor milestones, and better motor function than in historical cohorts.
Journal ArticleDOI
Astrocytes from familial and sporadic ALS patients are toxic to motor neurons
Amanda M. Haidet-Phillips,Mark E. Hester,Carlos Henrique Miranda,Kathrin Meyer,Lyndsey Braun,Ashley E. Frakes,Ashley E. Frakes,SungWon Song,SungWon Song,Shibi Likhite,Shibi Likhite,Matthew J. Murtha,Matthew J. Murtha,Kevin D. Foust,Meghan Rao,Amy Eagle,Anja Kammesheidt,Ashley Christensen,Jerry R. Mendell,Jerry R. Mendell,Arthur H.M. Burghes,Brian K. Kaspar +21 more
TL;DR: It is demonstrated that astrocytes derived from postmortem tissue from both FALS and SALS patients are similarly toxic to motor neurons and that SOD1 is a viable target for SALS, as its knockdown significantly attenuatesAstrocyte-mediated toxicity toward motor neurons.
Journal ArticleDOI
SARS-CoV-2-triggered neutrophil extracellular traps mediate COVID-19 pathology.
Flávio P. Veras,Marjorie Cornejo Pontelli,Camila Meirelles de Souza Silva,Juliana E Toller-Kawahisa,Mikhael de Lima,Daniele C. Nascimento,Ayda Henriques Schneider,Diego B. Caetite,Lucas Alves Tavares,Isadora Marques Paiva,Roberta Ribeiro Costa Rosales,David F. Colón,Ronaldo B. Martins,Italo A. Castro,Glaucia M. Almeida,Maria Isabel Fernandes Lopes,Maira N. Benatti,Letícia Pastorelli Bonjorno,Marcela C Giannini,Rodrigo Luppino-Assad,Sérgio C. L. Almeida,Fernando Crivelenti Vilar,Rodrigo de Carvalho Santana,Valdes Roberto Bollela,Maria Auxiliadora-Martins,Marcos C. Borges,Carlos Henrique Miranda,Antonio Pazin-Filho,Luis Lamberti Pinto da Silva,Larissa D. Cunha,Dario S. Zamboni,Felipe Dal-Pizzol,Luiz O. Leiria,Li Siyuan,Sabrina Setembre Batah,Alexandre Todorovic Fabro,Thais Mauad,Marisa Dolhnikoff,Amaro Nunes Duarte-Neto,Paulo Hilário Nascimento Saldiva,Thiago M. Cunha,José C. Alves-Filho,Eurico Arruda,Paulo Louzada-Junior,Renê Donizeti Ribeiro de Oliveira,Fernando Q. Cunha +45 more
TL;DR: It is described that SARS-CoV-2 triggers the release of ACE2-depended neutrophil extracellular traps (NETs) that mediate lung pathology, supporting the use of NETs inhibitors for COVID-19 treatment.
Journal ArticleDOI
Microglia induce motor neuron death via the classical NF-κB pathway in amyotrophic lateral sclerosis
Ashley E. Frakes,Laura Ferraiuolo,Amanda M. Haidet-Phillips,Leah Schmelzer,Lyndsey Braun,Carlos Henrique Miranda,Katherine J. Ladner,Adam K. Bevan,Adam K. Bevan,Kevin D. Foust,Jonathan P. Godbout,Phillip G. Popovich,Denis C. Guttridge,Brian K. Kaspar,Brian K. Kaspar +14 more
TL;DR: This study shows that selective NF-κB inhibition in ALS astrocytes is not sufficient to rescue motor neuron (MN) death, and suggests a novel therapeutic target that can be modulated to slow the progression of ALS and possibly other neurodegenerative diseases by which microglial activation plays a role.
Journal ArticleDOI
Direct conversion of patient fibroblasts demonstrates non-cell autonomous toxicity of astrocytes to motor neurons in familial and sporadic ALS.
Kathrin Meyer,Laura Ferraiuolo,Carlos Henrique Miranda,Shibi Likhite,Shibi Likhite,Sohyun McElroy,Samantha R. Renusch,Dara Ditsworth,Clotilde Lagier-Tourenne,Richard A. G. Smith,John Ravits,Arthur H.M. Burghes,Pamela J. Shaw,Don W. Cleveland,Stephen J. Kolb,Brian K. Kaspar,Brian K. Kaspar +16 more
TL;DR: Easy production and expansion of i-astrocytes now enables rapid disease modeling and high-throughput drug screening to alleviate astrocyte-derived toxicity, suggesting a common mechanism of ALS.