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Letícia Pastorelli Bonjorno
Researcher at University of São Paulo
Publications - 14
Citations - 1555
Letícia Pastorelli Bonjorno is an academic researcher from University of São Paulo. The author has contributed to research in topics: Medicine & Inflammasome. The author has an hindex of 7, co-authored 9 publications receiving 601 citations.
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Journal ArticleDOI
SARS-CoV-2-triggered neutrophil extracellular traps mediate COVID-19 pathology.
Flávio P. Veras,Marjorie Cornejo Pontelli,Camila Meirelles de Souza Silva,Juliana E Toller-Kawahisa,Mikhael de Lima,Daniele C. Nascimento,Ayda Henriques Schneider,Diego B. Caetite,Lucas Alves Tavares,Isadora Marques Paiva,Roberta Ribeiro Costa Rosales,David F. Colón,Ronaldo B. Martins,Italo A. Castro,Glaucia M. Almeida,Maria Isabel Fernandes Lopes,Maira N. Benatti,Letícia Pastorelli Bonjorno,Marcela C Giannini,Rodrigo Luppino-Assad,Sérgio C. L. Almeida,Fernando Crivelenti Vilar,Rodrigo de Carvalho Santana,Valdes Roberto Bollela,Maria Auxiliadora-Martins,Marcos C. Borges,Carlos Henrique Miranda,Antonio Pazin-Filho,Luis Lamberti Pinto da Silva,Larissa D. Cunha,Dario S. Zamboni,Felipe Dal-Pizzol,Luiz O. Leiria,Li Siyuan,Sabrina Setembre Batah,Alexandre Todorovic Fabro,Thais Mauad,Marisa Dolhnikoff,Amaro Nunes Duarte-Neto,Paulo Hilário Nascimento Saldiva,Thiago M. Cunha,José C. Alves-Filho,Eurico Arruda,Paulo Louzada-Junior,Renê Donizeti Ribeiro de Oliveira,Fernando Q. Cunha +45 more
TL;DR: It is described that SARS-CoV-2 triggers the release of ACE2-depended neutrophil extracellular traps (NETs) that mediate lung pathology, supporting the use of NETs inhibitors for COVID-19 treatment.
Journal ArticleDOI
Inflammasomes are activated in response to SARS-CoV-2 infection and are associated with COVID-19 severity in patients.
Tamara S Rodrigues,Keyla Santos Guedes de Sá,Adriene Y. Ishimoto,Amanda Becerra,Samuel L. Oliveira,Letícia Yamawaka de Almeida,Augusto V. Gonçalves,Debora B. Perucello,Warrison A. Andrade,Ricardo M. C. Castro,Flávio P. Veras,Juliana E Toller-Kawahisa,Daniele C. Nascimento,Mikhael Haruo Fernandes de Lima,Camila Meirelles de Souza Silva,Diego B. Caetite,Ronaldo B. Martins,Italo A. Castro,Marjorie Cornejo Pontelli,Fábio Cury de Barros,Fábio Cury de Barros,Natalia B. do Amaral,Marcela C Giannini,Letícia Pastorelli Bonjorno,Maria Isabel Fernandes Lopes,Rodrigo de Carvalho Santana,Fernando Crivelenti Vilar,Maria Auxiliadora-Martins,Rodrigo Luppino-Assad,Sérgio C. L. Almeida,Fabiola Reis de Oliveira,Sabrina Setembre Batah,Li Siyuan,Maira N. Benatti,Thiago M. Cunha,José C. Alves-Filho,Fernando Q. Cunha,Larissa D. Cunha,Fabiani Gai Frantz,Tiana Kohlsdorf,Alexandre Todorovic Fabro,Eurico Arruda,Renê Donizeti Ribeiro de Oliveira,Paulo Louzada-Junior,Dario S. Zamboni +44 more
TL;DR: This work shows that inflammasomes are activated in response to SARS-CoV-2 infection in vitro and in COVID-19 patients, contributing to the exacerbated inflammatory response, impacting disease progression and clinical outcome.
Journal ArticleDOI
Beneficial effects of colchicine for moderate to severe COVID-19: a randomised, double-blinded, placebo-controlled clinical trial.
Maria Isabel Lopes,Letícia Pastorelli Bonjorno,Marcela C Giannini,Natalia B. do Amaral,Pamella Indira Da Silva Oliveira Menezes,Saulo Musse Dib,Samara Libich Gusmão Gigante,Maira N. Benatti,Uebe C Rezek,Laerte L Emrich-Filho,Betania A A Sousa,Sérgio C. L. Almeida,Rodrigo Luppino Assad,Flávio P. Veras,Ayda Henriques Schneider,Tamara S Rodrigues,Luiz O. Leiria,Larissa D. Cunha,José C. Alves-Filho,Thiago M. Cunha,Eurico Arruda,Carlos Henrique Miranda,Antonio Pazin-Filho,Maria Auxiliadora-Martins,Marcos C. Borges,Benedito Antonio Lopes da Fonseca,Valdes Roberto Bollela,Cristina Marta Del-Ben,Fernando Q. Cunha,Dario S. Zamboni,Rodrigo de Carvalho Santana,Fernando Crivelenti Vilar,Paulo Louzada-Junior,Renê Donizeti Ribeiro de Oliveira +33 more
TL;DR: In this article, a randomized, double-blinded, placebo-controlled clinical trial of colchicine for the treatment of moderate to severe COVID-19, with 75 patients allocated 1:1 from 11 April to 30 August 2020, was presented.
Posted ContentDOI
Infection of human lymphomononuclear cells by SARS-CoV-2
Marjorie Cornejo Pontelli,Italo A. Castro,Ronaldo B. Martins,Flávio P. Veras,Leonardo La Serra,Daniele C. Nascimento,Ricardo S. Cardoso,Roberta Ribeiro Costa Rosales,Thais Martins de Lima,Juliano de Paula Souza,Diego B. Caetite,Mikhael Hf de Lima,Juliana T Kawahisa,Marcela C Giannini,Letícia Pastorelli Bonjorno,Maria I. F. Lopes,Sabrina Setembre Batah,Li Siyuan,Rodrigo Luppino Assad,Sergio Cl Almeida,Fabiola Reis Oliveira,Maira N. Benatti,Lorena Lf Pontes,Rodrigo de Carvalho Santana,Fernando C Villar,Maria Auxiliadora Martins,Thiago M. Cunha,Rodrigo T Calado,José C. Alves-Filho,Dario S. Zamboni,Alexandre Todorovic Fabro,Paulo Louzada-Junior,Rene Dr de Oliveira,Fernando Q. Cunha,Eurico Arruda +34 more
TL;DR: In this study, in vitro infection of whole PBMCs from healthy donors was productive of virus progeny and results revealed that monocytes, as well as B and T lymphocytes, are susceptible to SARS-CoV-2 active infection and viral replication was indicated by detection of double-stranded RNA.
Posted ContentDOI
SARS-CoV-2 triggered neutrophil extracellular traps (NETs) mediate COVID-19 pathology
Flávio P. Veras,Marjorie Cornejo Pontelli,Camila S. Silva,Juliana E Toller-Kawahisa,Mikhael de Lima,Daniele C. Nascimento,Ayda Henriques Schneider,Diego B. Caetite,Roberta Ribeiro Costa Rosales,David F. Colón,Ronaldo Teixeira Martins,Italo A. Castro,Glaucia M. Almeida,Maria Isabel Lopes,Maira N. Benatti,Letícia Pastorelli Bonjorno,Marcela C Giannini,Rodrigo Luppino-Assad,Sérgio Mendonça de Almeida,Fernando Crivelenti Vilar,Rodrigo de Carvalho Santana,Valdes Roberto Bollela,Maria Lucia Refinetti Rodrigues Martins,Carlos Henrique Miranda,Marcos C. Borges,Antonio Pazin-Filho,Larissa D. Cunha,Dario S. Zamboni,Felipe Dal-Pizzol,Luiz O. Leiria,Li Siyuan,Sabrina Setembre Batah,Alexandre Todorovic Fabro,Thais Mauad,Marisa Dolhnikoff,Amaro Nunes Duarte-Neto,Paulo Hilário Nascimento Saldiva,Thiago M. Cunha,José C. Alves-Filho,Eurico Arruda,Paulo Louzada-Junior,Renê Donizeti Ribeiro de Oliveira,Fernando Q. Cunha +42 more
TL;DR: Results unravel a possible detrimental role of NETs in the pathophysiology of COVID-19 and suggest that the inhibition ofNETs represent a potential therapeutic target for CO VID-19.