J
Juliana M. Chan
Researcher at Massachusetts Institute of Technology
Publications - 23
Citations - 6317
Juliana M. Chan is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Drug delivery & Aptamer. The author has an hindex of 15, co-authored 23 publications receiving 5729 citations. Previous affiliations of Juliana M. Chan include Brigham and Women's Hospital & Nanyang Technological University.
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Journal ArticleDOI
Nanoparticles in Medicine: Therapeutic Applications and Developments
TL;DR: Nanomaterials have unique physicochemical properties, such as ultra small size, large surface area to mass ratio, and high reactivity, which are different from bulk materials of the same composition, which can be used to overcome some of the limitations found in traditional therapeutic and diagnostic agents.
Journal ArticleDOI
Self-assembled lipid--polymer hybrid nanoparticles: a robust drug delivery platform.
Liangfang Zhang,Juliana M. Chan,Frank X. Gu,June-Wha Rhee,Andrew Z. Wang,Andrew Z. Wang,Aleksandar Filip Radovic-Moreno,Frank Alexis,Frank Alexis,Robert Langer,Omid C. Farokhzad +10 more
TL;DR: The engineering of a novel lipid-polymer hybrid nanoparticle (NP) as a robust drug delivery platform, with high drug encapsulation yield, tunable and sustained drug release profile, excellent serum stability, and potential for differential targeting of cells or tissues is reported.
Journal ArticleDOI
pH-Responsive nanoparticles for drug delivery.
TL;DR: The novel developments described here may revise the classical outlook that NPs are passive delivery vehicles, in favor of responsive, sensing vehicles that use environmental cues to achieve maximal drug potency.
Journal ArticleDOI
PLGA-lecithin-PEG core-shell nanoparticles for controlled drug delivery.
Juliana M. Chan,Liangfang Zhang,Kai P. Yuet,Grace V. Liao,June-Wha Rhee,Robert Langer,Omid C. Farokhzad +6 more
TL;DR: The data suggest that the PLGA-lecithin-PEG core-shell NPs may be a useful new controlled release drug delivery system.
Book ChapterDOI
Polymeric nanoparticles for drug delivery.
TL;DR: This chapter describes the methods of preparation and characterization of drug-encapsulated polymeric NPs formulated with biocompatible and biodegradable poly(D,L-lactic-co-glycolic acid)-poly(ethylene glycol) (PLGA-b-PEG) copolymers and their evaluation of the binding properties to PSMA-expressing prostate cancer cells in vitro and in vivo.