D
Duran Ustek
Researcher at Istanbul University
Publications - 91
Citations - 2610
Duran Ustek is an academic researcher from Istanbul University. The author has contributed to research in topics: MEFV & Familial Mediterranean fever. The author has an hindex of 22, co-authored 91 publications receiving 2276 citations. Previous affiliations of Duran Ustek include Istanbul Medipol University & St. Jude Children's Research Hospital.
Papers
More filters
Journal ArticleDOI
Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with Behcet's disease
Elaine F. Remmers,Fulya Cosan,Yohei Kirino,Michael J. Ombrello,Neslihan Abaci,Colleen Satorius,Julie M. Le,Barbara Yang,Benjamin D. Korman,Aris Cakiris,Oznur Aglar,Zeliha Emrence,Hulya Azakli,Duran Ustek,Ilknur Tugal-Tutkun,Gulsen Akman-Demir,Wei-Wei Chen,Christopher I. Amos,Michael B. Dizon,Afet Akdag Kose,Gülsevim Azizlerli,Burak Erer,Oliver J. Brand,Virginia G. Kaklamani,Phaedon G. Kaklamanis,Eldad Ben-Chetrit,Miles Stanford,Farida Fortune,Marwen Ghabra,William E R Ollier,Young-Hun Cho,Dongsik Bang,John M O'Shea,Graham R. Wallace,Massimo Gadina,Daniel L. Kastner,Ahmet Gül +36 more
TL;DR: The known association of Behçet's disease with HLA-B*51 was confirmed and a second, independent association within the MHC Class I region was identified and the disease-associated IL10 variant was associated with diminished mRNA expression and low protein production.
Journal ArticleDOI
Genome-wide association analysis identifies new susceptibility loci for Behçet's disease and epistasis between HLA-B*51 and ERAP1
Yohei Kirino,George Bertsias,George Bertsias,Yoshiaki Ishigatsubo,Nobuhisa Mizuki,Ilknur Tugal-Tutkun,Emire Seyahi,Yilmaz Ozyazgan,F Sevgi Sacli,Burak Erer,Hidetoshi Inoko,Zeliha Emrence,Atilla Cakar,Neslihan Abaci,Duran Ustek,Colleen Satorius,Atsuhisa Ueda,Mitsuhiro Takeno,Yoonhee Kim,Geryl Wood,Michael J. Ombrello,Akira Meguro,Ahmet Gül,Elaine F. Remmers,Daniel L. Kastner +24 more
TL;DR: A genome-wide association study of 779,465 SNPs with imputed genotypes in 1,209 Turkish individuals with Behçet's disease and 1,278 controls found new associations at CCR1, STAT4 and KLRC4, and found evidence for interaction between HLA-B*51 and ERAP1.
Journal ArticleDOI
Targeted resequencing implicates the familial Mediterranean fever gene MEFV and the toll-like receptor 4 gene TLR4 in Behçet disease
Yohei Kirino,Qing Zhou,Yoshiaki Ishigatsubo,Nobuhisa Mizuki,Ilknur Tugal-Tutkun,Emire Seyahi,Yilmaz Ozyazgan,Serdal Ugurlu,Burak Erer,Neslihan Abaci,Duran Ustek,Akira Meguro,Atsuhisa Ueda,Mitsuhiro Takeno,Hidetoshi Inoko,Michael J. Ombrello,Colleen Satorius,Baishali Maskeri,James C. Mullikin,Hong-Wei Sun,Gustavo Gutierrez-Cruz,Yoonhee Kim,Alexander F. Wilson,Daniel L. Kastner,Ahmet Gül,Elaine F. Remmers +25 more
TL;DR: The disease-associated NSVs in MEFV and TLR4 implicate innate immune and bacterial sensing mechanisms in BD pathogenesis and are associated with BD.
Journal ArticleDOI
Metagenomic analysis of the microbial community in kefir grains
Ufuk Nalbantoglu,Atilla Cakar,Haluk Dogan,Neslihan Abaci,Duran Ustek,Khalid Sayood,Handan Can +6 more
TL;DR: The results suggest that microbial community profiling using whole genome shotgun data is feasible, can identify novel species data, and has the potential to generate a more accurate and detailed assessment of the underlying bacterial community, especially for low abundance species.
Journal ArticleDOI
Dense genotyping of immune-related loci implicates host responses to microbial exposure in Behçet's disease susceptibility.
Masaki Takeuchi,Masaki Takeuchi,Nobuhisa Mizuki,Akira Meguro,Michael J. Ombrello,Yohei Kirino,Colleen Satorius,Julie Le,Mary Blake,Burak Erer,Tatsukata Kawagoe,Duran Ustek,Ilknur Tugal-Tutkun,Emire Seyahi,Yilmaz Ozyazgan,Inês Sousa,Inês Sousa,Fereydoun Davatchi,Vânia Francisco,Vânia Francisco,Farhad Shahram,Bahar Sadeghi Abdollahi,Abdolhadi Nadji,Niloofar Mojarad Shafiee,Fahmida Ghaderibarmi,Shigeaki Ohno,Atsuhisa Ueda,Yoshiaki Ishigatsubo,Massimo Gadina,Sofia A. Oliveira,Sofia A. Oliveira,Ahmet Gül,Daniel L. Kastner,Elaine F. Remmers +33 more
TL;DR: The findings extend the list of susceptibility genes shared with Crohn's disease and leprosy and implicate mucosal factors and the innate immune response to microbial exposure in Behçet's disease susceptibility.