Julie N.O. Denoeud

TL;DR: The potential role of the CD27/CD70 pathway in the course of inflammatory diseases, as in EAE, arthritis, and inflammatory bowel disease models, suggests that CD70 may be a target for immune intervention, and the potency of costimulation through CD27 suggests that the CD70/CD27 axis could be exploited for the design of anti‐cancer vaccines.

TL;DR: It is shown that early after infection, these parasites subvert the first line of innate host defense by inhibiting tumor necrosis factor-α synthesis in myeloid cells, which provides a long-sought function for the abundant and diverse adenylate cyclases in salivarian trypanosomes.

TL;DR: Observations emphasise the synergy between IL-10 and IDO as anti-inflammatory agents and highlight anti-CTLA-4 treatment as a potential novel immunotherapeutic approach for inducing adaptive regulatory T cells.

TL;DR: It is demonstrated that tTregs selectively inhibit CD27/CD70‐dependent Th1 priming, while leaving the IL‐12‐dependent pathway unaffected.