T
Tim Sparwasser
Researcher at University of Mainz
Publications - 236
Citations - 21756
Tim Sparwasser is an academic researcher from University of Mainz. The author has contributed to research in topics: FOXP3 & Immune system. The author has an hindex of 70, co-authored 229 publications receiving 19018 citations. Previous affiliations of Tim Sparwasser include Hannover Medical School & Technische Universität München.
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Journal ArticleDOI
Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease.
Katharina Lahl,Christoph Loddenkemper,Cathy E Drouin,Jennifer Freyer,Jon Arnason,Gérard Eberl,Alf Hamann,Hermann Wagner,Jochen Huehn,Tim Sparwasser +9 more
TL;DR: Experimental evidence that the absence of Foxp3+ T reg cells is indeed sufficient to induce a scurfy-like phenotype is provided, and the generation of DEREG mice will allow a more precise definition of the function of Fox p3+T reg cells in immune reactions in vivo.
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Bacterial DNA and immunostimulatory CpG oligonucleotides trigger maturation and activation of murine dendritic cells
Tim Sparwasser,Eva Sophie Koch,Ramunas M. Vabulas,Klaus Heeg,Grayson B. Lipford,Joachim W. Ellwart,Hermann Wagner +6 more
TL;DR: It is demonstrated that bacterial DNA or i.s. CpG‐ODN cause maturation and activation of DC to bring about conversion of immature DC into professional APC, which is associated with the acquisition of professional antigen‐presenting cell (APC) function.
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Card9 controls a non-TLR signalling pathway for innate anti-fungal immunity
Olaf Gross,Andreas Gewies,Katrin Finger,Martin Schäfer,Tim Sparwasser,Christian Peschel,Irmgard Förster,Irmgard Förster,Jürgen Ruland +8 more
TL;DR: A novel innate immune pathway is defined and it is indicated that evolutionarily distinct ITAM receptors in innate and adaptive immune cells use diverse adaptor proteins to engage selectively the conserved Bcl10–Malt1 module.
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Intestinal tolerance requires gut homing and expansion of FoxP3+ regulatory T cells in the lamina propria
Usriansyah Hadis,Benjamin Wahl,Olga Schulz,Matthias Hardtke-Wolenski,Angela Schippers,Norbert Wagner,Werner Müller,Tim Sparwasser,Reinhold Förster,Oliver Pabst +9 more
TL;DR: A model of stepwise oral tolerance induction induction comprising the generation of Treg cells in the gut-draining lymph nodes, followed by migration into the gut and subsequent expansion of T Reg cells driven by intestinal macrophages is proposed.
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CpG-DNA-specific activation of antigen-presenting cells requires stress kinase activity and is preceded by non-specific endocytosis and endosomal maturation.
Hans Häcker,Harald Mischak,Thomas Miethke,Susanne Liptay,Roland M. Schmid,Tim Sparwasser,Klaus Heeg,Grayson B. Lipford,Hermann Wagner +8 more
TL;DR: It is demonstrated that CpG‐DNA induces phosphorylation of Jun N‐terminal kinase kinase 1 (JNKK1/SEK/MKK4) and subsequent activation of the stress kinases JNK1/2 and p38 in murine macrophages and dendritic cells, and that cellular uptake via endocytosis and subsequent endosomal maturation is essential for signalling.