Julie Webster

TL;DR: Results show that the percentage of AGE-positive neurons (and astroglia) increase both with age and, in AD patients, with the progression of the disease (Braak stages).

TL;DR: A novel role for CCR6 is demonstrated in the mechanism of autoreactive lymphocyte priming and emigration to the efferent lymphatics of autoimmune encephalomyelitis.

TL;DR: This review provides an updated and concise summary of recent studies on mosquito antiviral immune responses, which is a key determinant for successful virus transmission and current mosquito transmission-blocking strategies that utilize genetically modified mosquitoes and Wolbachia-infected mosquitoes for resistance to pathogens.

TL;DR: Pre-incubation of methylglyoxal with a variety of carbonyl scavengers such as aminoguanidine or tenilsetam and the thiol antioxidant lipoic acid significantly reduced its toxicity, suggesting carbony l scavengers might offer a promising therapeutic strategy to reduce the neurotoxicity of reactive carbonyL compounds.

TL;DR: Data demonstrate that the IMPDH isoforms are differentially regulated by AMP and ATP by a mechanism involving the Bateman domain, communication occurs between the Batemen and catalytic domains and the RP-causing mutations compromise such regulation.