W
Wai-Suet Lee
Researcher at University of Southern California
Publications - 4
Citations - 116
Wai-Suet Lee is an academic researcher from University of Southern California. The author has contributed to research in topics: Viral replication & Zika virus. The author has an hindex of 3, co-authored 3 publications receiving 60 citations. Previous affiliations of Wai-Suet Lee include Griffith University.
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Journal ArticleDOI
Mosquito antiviral defense mechanisms: a delicate balance between innate immunity and persistent viral infection.
TL;DR: This review provides an updated and concise summary of recent studies on mosquito antiviral immune responses, which is a key determinant for successful virus transmission and current mosquito transmission-blocking strategies that utilize genetically modified mosquitoes and Wolbachia-infected mosquitoes for resistance to pathogens.
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Biomarkers and immunoprofiles associated with fetal abnormalities of ZIKV-positive pregnancies
Suan-Sin Foo,Weiqiang Chen,Yen Chan,Wai-Suet Lee,Shin-Ae Lee,Genhong Cheng,Karin Nielsen-Saines,Patrícia Brasil,Jae U. Jung +8 more
TL;DR: Intriguingly, the high CCL2 level and its inverse correlation with CD163, TNFRSF1A, and CCL22 levels was apparently associated with ZIKV-induced abnormal birth.
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Zika virus NS3 protease induces bone morphogenetic protein-dependent brain calcification in human fetuses
Weiqiang Chen,Suan-Sin Foo,Eun-Jin Hong,Christine Wu,Wai-Suet Lee,Shin-Ae Lee,Denis Evseenko,Maria Elisabeth Lopes Moreira,Adolfo García-Sastre,Genhong Cheng,Karin Nielsen-Saines,Patrícia Brasil,Elyzabeth Avvad-Portari,Jae U. Jung +13 more
TL;DR: It is shown that ZIKV infection of cultivated primary human brain pericytes triggers BMP2 maturation, leading to osteogenic gene expression and calcification, and that the NS3 protease subverts the B MP2-mediated osteogenic signaling pathway to trigger brain calcification.
Journal ArticleDOI
TMEM41B and VMP1 modulate cellular lipid and energy metabolism for facilitating dengue virus infection
Meisam Yousefi,Wai-Suet Lee,Biao Yan,Liang Cui,Cythia Lingli Yong,Xin Yap,Kwan Sing Leona Tay,Wenjie Qiao,Dewei Tan,Nur Insyirah Nurazmi,Martin Linster,Gavin J. D. Smith,Yie Hou Lee,Jan E. Carette,Eng Eong Ooi,Kuan Rong Chan,Yaw Shin Ooi +16 more
TL;DR: This work validated that both TMEM41B and VMP1 are essential host dependency factors for all four serotypes of dengue virus (DENV) and human coronavirus OC43 (HCoV-OC43), but not chikungunya virus (CHIKV), and revealed distinctive global dysregulations of the cellular metabolome, particularly lipidome, in TMEM 41B- and V MP1-deficient cells.