Julien Lefèvre

TL;DR: An early and marked impairment of microtubule dynamics all along the axons of spastin-deficient cortical neurons, which is likely to be responsible for the occurrence of axonal swellings and cargo stalling, contributes to a better understanding of the pathogenesis of SPG4-linked HSP and ascertain the influence of micro Tubule-targeted drugs on the early axonal phenotype in a mouse model of the disease.

TL;DR: The interaction of Tau, spermine, and calcium, three representative partners of the tubulin C-terminal region, with a peptide composed of the last 42 residues of α1a-tubulin is studied to provide a structural basis for a better understanding of the complex interactions and putative competition of tubulin cationic partners with the C-Terminal region of Tubulin.

TL;DR: A basis for a better understanding of the role played by polyamines in MT assembly is provided and polyamine metabolism is established as a potential cellular target for modulating MT functions.

TL;DR: It is shown that a short protein fragment from MAP6-N, which encompasses its Mn1 and Mn2 modules (MAP6(90–177), recapitulates the function of the full-length MAP 6-N protein toward microtubules, i.e. its ability to stabilize microtubule in vitro and in cultured cells in ice-cold conditions or in the presence of nocodazole.