P
Paul A. Ginno
Researcher at Friedrich Miescher Institute for Biomedical Research
Publications - 11
Citations - 2891
Paul A. Ginno is an academic researcher from Friedrich Miescher Institute for Biomedical Research. The author has contributed to research in topics: DNA methylation & Methylation. The author has an hindex of 8, co-authored 9 publications receiving 2155 citations. Previous affiliations of Paul A. Ginno include University of California, Davis.
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Journal ArticleDOI
Impact of cytosine methylation on DNA binding specificities of human transcription factors.
Yimeng Yin,Ekaterina Morgunova,Arttu Jolma,Eevi Kaasinen,Biswajyoti Sahu,Syed Khund-Sayeed,Pratyush Kumar Das,Teemu Kivioja,Kashyap Dave,Fan Zhong,Kazuhiro R. Nitta,Minna Taipale,Alexander Popov,Paul A. Ginno,Silvia Domcke,Silvia Domcke,Jian Yan,Dirk Schübeler,Dirk Schübeler,Charles Vinson,Jussi Taipale,Jussi Taipale +21 more
TL;DR: This work systematically analyzed binding specificities of full-length transcription factors and extended DNA binding domains to unmethylated and CpG-methylated DNA by using methylation-sensitive SELEX (systematic evolution of ligands by exponential enrichment).
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R-loop formation is a distinctive characteristic of unmethylated human CpG island promoters
TL;DR: It is reported that methylation-resistant CGI promoters are characterized by significant strand asymmetry in the distribution of guanines and cytosines immediately downstream from their transcription start sites, and it is shown that transcription through regions of GC skew leads to the formation of long R loop structures.
Journal ArticleDOI
Competition between DNA methylation and transcription factors determines binding of NRF1
Silvia Domcke,Silvia Domcke,Anaïs F. Bardet,Paul A. Ginno,Dominik Hartl,Dominik Hartl,Lukas Burger,Lukas Burger,Dirk Schübeler,Dirk Schübeler +9 more
TL;DR: This map of DNase-I-hypersensitive sites in murine stem cells reveals a case of cooperativity between TFs that acts indirectly via DNA methylation, and suggests that binding of DNA-methylation-sensitive TFs relies on additional determinants to induce local hypomethylation.
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Prevalent, Dynamic, and Conserved R-Loop Structures Associate with Specific Epigenomic Signatures in Mammals
Lionel A. Sanz,Stella R. Hartono,Yoong Wearn Lim,Sandra Steyaert,Aparna Rajpurkar,Paul A. Ginno,Xiaoqin Xu,Frédéric Chédin +7 more
TL;DR: It is suggested that the retention of nascent RNA transcripts at their site of expression represents an abundant, dynamic, and programmed component of the mammalian chromatin that affects chromatin patterning and the control of gene expression.
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GC skew at the 5′ and 3′ ends of human genes links R-loop formation to epigenetic regulation and transcription termination
TL;DR: It is shown that GC skew can distinguish four classes of promoters, including three types of CGI promoters, each associated with unique epigenetic and gene ontology signatures, and that nearly 2000 genes harbor GC skew at their 3' ends and that these genes are preferentially located in gene-dense regions and tend to be closely arranged.