Juliette Giacobbe

TL;DR: Overall, RvD and RvE treatment improved depressive-like behaviors, whereas protectins and maresins ameliorated neurological function, and a potential promising approach for tailored therapy with n-3 PUFAs-derived metabolites in the treatment of psychiatric, neurodegenerative, and neurological conditions is indicated.

TL;DR: In this article, the first evidence for the relevance of LOX and CYP450-derived EPA/DHA bioactive lipid metabolites as neuroprotective molecular targets for human hippocampal neurogenesis and depression was detected using mass spectrometry lipidomics of the supernatant.

TL;DR: It is demonstrated that IL6 can exert both pro- and anti-inflammatory properties, depending on its concentrations and combinations with other inflammatory cytokines.

TL;DR: The role of the endocannabinoid (eCB) system on the immune system and neurogenesis, as well as resulting behavioral effects in rodent models of affective disorders was investigated in this paper.

TL;DR: Regardless of treatment duration ECS would seemingly trigger a rapid increase in inflammatory molecules, dampened over time, as well as a long-lasting activation of astrocytes and production of growth and neurotrophic factors, leading to cell proliferation, which suggests that both innate immune system response and neurogenesis might contribute to the efficacy of ECT.