J
Julius C. R. Hafalla
Researcher at University of London
Publications - 79
Citations - 5190
Julius C. R. Hafalla is an academic researcher from University of London. The author has contributed to research in topics: Antigen & Immune system. The author has an hindex of 36, co-authored 73 publications receiving 4765 citations. Previous affiliations of Julius C. R. Hafalla include Research Institute for Tropical Medicine & Johns Hopkins University.
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Journal ArticleDOI
Migration of Plasmodium Sporozoites Through Cells Before Infection
Maria M. Mota,Gabriele Pradel,Jerome P. Vanderberg,Julius C. R. Hafalla,Ute Frevert,Ruth S. Nussenzweig,Victor Nussenzweig,Ana Rodriguez +7 more
TL;DR: Sporozoite migration through several cells in the mammalian host appears to be essential for the completion of the life cycle of Plasmodium sporozoites.
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Antigen targeting to dendritic cells elicits long-lived T cell help for antibody responses.
Silvia Beatriz Boscardin,Julius C. R. Hafalla,Revati F. Masilamani,Alice O. Kamphorst,Henry Zebroski,Urvashi Rai,Alexandre Morrot,Fidel Zavala,Ralph M. Steinman,Ruth S. Nussenzweig,Michel C. Nussenzweig +10 more
TL;DR: It is concluded that antigen targeting to DCs combined with a maturation stimulus produces broad-based and long-lived T cell help for humoral immune responses.
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IL-10 from CD4+CD25?Foxp3?CD127? Adaptive Regulatory T Cells Modulates Parasite Clearance and Pathology during Malaria Infection
Kevin N. Couper,Daniel G. Blount,Mark S. Wilson,Julius C. R. Hafalla,Yasmine Belkaid,Masahito Kamanaka,Richard A. Flavell,J. Brian de Souza,J. Brian de Souza,Eleanor M. Riley +9 more
TL;DR: A population of induced Foxp3− regulatory (Tr1) T cells, characterised by production of IL-10 and down regulation ofIL-7Rα, that modulates the inflammatory response to malaria are identified.
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Long-lived antibody and B Cell memory responses to the human malaria parasites, Plasmodium falciparum and Plasmodium vivax.
Jiraprapa Wipasa,Chaisuree Suphavilai,Lucy C Okell,Jackie Cook,Patrick H. Corran,Kanitta Thaikla,Witaya Liewsaree,Eleanor M. Riley,Julius C. R. Hafalla +8 more
TL;DR: Analysis of the longevity of both antibody and B cell memory responses to malaria antigens among individuals who were living in an area of extremely low malaria transmission in northern Thailand concludes that infrequent malaria infections are capable of inducing long-lived antibody and memory B cell responses.
Journal ArticleDOI
Detection of malaria liver-stages in mice infected through the bite of a single Anopheles mosquito using a highly sensitive real-time PCR
Oscar Bruna-Romero,Julius C. R. Hafalla,Gloria Gonzalez-Aseguinolaza,Gen-ichiro Sano,Moriya Tsuji,Fidel Zavala +5 more
TL;DR: A highly sensitive real-time PCR to detect and measure the development of the liver-stages of malaria parasites in mice infected with sporozoites ranging in number from 25 to more than 164,000, using the same reaction conditions.