J
Jun Kurokawa
Researcher at University of Tokyo
Publications - 8
Citations - 483
Jun Kurokawa is an academic researcher from University of Tokyo. The author has contributed to research in topics: Adipose tissue & Inflammation. The author has an hindex of 8, co-authored 8 publications receiving 411 citations.
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Journal ArticleDOI
Macrophage-Derived AIM Is Endocytosed into Adipocytes and Decreases Lipid Droplets via Inhibition of Fatty Acid Synthase Activity
Jun Kurokawa,Satoko Arai,Katsuhiko Nakashima,Hiromichi Nagano,Akemi Nishijima,Keishi Miyata,Rui Ose,Mayumi Mori,Naoto Kubota,Takashi Kadowaki,Yuichi Oike,Hisashi Koga,Maria Febbraio,Toshihiko Iwanaga,Toru Miyazaki +14 more
TL;DR: It is shown that the macrophage-derived soluble protein AIM is endocytosed into adipocytes via CD36, and this AIM function in adipocytes may be physiologically relevant to obesity progression.
Journal ArticleDOI
Obesity-Associated Autoantibody Production Requires AIM to Retain the Immunoglobulin M Immune Complex on Follicular Dendritic Cells
Satoko Arai,Natsumi Maehara,Yoshihiro Iwamura,Shin-ichiro Honda,Katsuhiko Nakashima,Toshihiro Kai,Masato Ogishi,Kumiko Morita,Jun Kurokawa,Mayumi Mori,Yuji Motoi,Kensuke Miyake,Nobuyuki Matsuhashi,Ken Ichi Yamamura,Osamu Ohara,Akira Shibuya,Edward K. Wakeland,Quan Zhen Li,Toru Miyazaki +18 more
TL;DR: The AIM-IgM association plays a critical role in the obesity-associated autoimmune process, and the increase of multiple IgG autoantibodies observed in obese wild-type mice was abrogated.
Journal ArticleDOI
Apoptosis inhibitor of macrophage (AIM) is required for obesity-associated recruitment of inflammatory macrophages into adipose tissue
Jun Kurokawa,Hiromichi Nagano,Osamu Ohara,Naoto Kubota,Takashi Kadowaki,Satoko Arai,Toru Miyazaki +6 more
TL;DR: The results indicate that the increase in blood AIM is a critical event for the initiation of macrophage recruitment into adipose tissue, which is followed by insulin resistance, and AIM suppression might be therapeutically applicable for the prevention of obesity-related metabolic disorders.
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Circulating AIM prevents hepatocellular carcinoma through complement activation
Natsumi Maehara,Satoko Arai,Mayumi Mori,Yoshihiro Iwamura,Jun Kurokawa,Toshihiro Kai,Shunsuke Kusunoki,Kaori Taniguchi,Kazutaka Ikeda,Osamu Ohara,Ken Ichi Yamamura,Toru Miyazaki +11 more
TL;DR: This work shows the potent anti-HCC effect of the circulating protein AIM, which prevented tumor development in AIM(-/-) mice, and HCC induction by diethylnitrosamine was more prominent in A IM (-/-) than wild-type mice.
Journal ArticleDOI
Death effector domain-containing protein (DEDD) is required for uterine decidualization during early pregnancy in mice
Mayumi Mori,Miwako Kitazume,Rui Ose,Jun Kurokawa,Kaori Koga,Yutaka Osuga,Satoko Arai,Toru Miyazaki +7 more
TL;DR: It is shown that female mice lacking death effector domain-containing protein (DEDD) are infertile owing to unsuccessful decidualization, and that DEDD is indispensable for the establishment of an adequate uterine environment to support early pregnancy in mice.