Institution
Nippon Telegraph and Telephone
Company•Tokyo, Japan•
About: Nippon Telegraph and Telephone is a company organization based out in Tokyo, Japan. It is known for research contribution in the topics: Optical fiber & Laser. The organization has 12831 authors who have published 22335 publications receiving 430492 citations. The organization is also known as: Nippon Denshin Denwa Kabushiki-gaisha & NTT.
Papers published on a yearly basis
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TL;DR: Detailed polling of transcription start and termination sites and analysis of previously unidentified full-length complementary DNAs derived from the mouse genome provide a comprehensive platform for the comparative analysis of mammalian transcriptional regulation in differentiation and development.
Abstract: This study describes comprehensive polling of transcription start and termination sites and analysis of previously unidentified full-length complementary DNAs derived from the mouse genome. We identify the 5' and 3' boundaries of 181,047 transcripts with extensive variation in transcripts arising from alternative promoter usage, splicing, and polyadenylation. There are 16,247 new mouse protein-coding transcripts, including 5154 encoding previously unidentified proteins. Genomic mapping of the transcriptome reveals transcriptional forests, with overlapping transcription on both strands, separated by deserts in which few transcripts are observed. The data provide a comprehensive platform for the comparative analysis of mammalian transcriptional regulation in differentiation and development.
3,412 citations
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TL;DR: Compared with SRS alone, the use of W BRT plus SRS did not improve survival for patients with 1 to 4 brain metastases, but intracranial relapse occurred considerably more frequently in those who did not receive WBRT.
Abstract: ContextIn patients with brain metastases, it is unclear whether adding up-front whole-brain radiation therapy (WBRT) to stereotactic radiosurgery (SRS) has beneficial effects on mortality or neurologic function compared with SRS alone.ObjectiveTo determine if WBRT combined with SRS results in improvements in survival, brain tumor control, functional preservation rate, and frequency of neurologic death.Design, Setting, and PatientsRandomized controlled trial of 132 patients with 1 to 4 brain metastases, each less than 3 cm in diameter, enrolled at 11 hospitals in Japan between October 1999 and December 2003.InterventionsPatients were randomly assigned to receive WBRT plus SRS (65 patients) or SRS alone (67 patients).Main Outcome MeasuresThe primary end point was overall survival; secondary end points were brain tumor recurrence, salvage brain treatment, functional preservation, toxic effects of radiation, and cause of death.ResultsThe median survival time and the 1-year actuarial survival rate were 7.5 months and 38.5% (95% confidence interval, 26.7%-50.3%) in the WBRT + SRS group and 8.0 months and 28.4% (95% confidence interval, 17.6%-39.2%) for SRS alone (P = .42). The 12-month brain tumor recurrence rate was 46.8% in the WBRT + SRS group and 76.4% for SRS alone group (P<.001). Salvage brain treatment was less frequently required in the WBRT + SRS group (n = 10) than with SRS alone (n = 29) (P<.001). Death was attributed to neurologic causes in 22.8% of patients in the WBRT + SRS group and in 19.3% of those treated with SRS alone (P = .64). There were no significant differences in systemic and neurologic functional preservation and toxic effects of radiation.ConclusionsCompared with SRS alone, the use of WBRT plus SRS did not improve survival for patients with 1 to 4 brain metastases, but intracranial relapse occurred considerably more frequently in those who did not receive WBRT. Consequently, salvage treatment is frequently required when up-front WBRT is not used.Trial Registrationumin.ac.jp/ctr Identifier: C000000412
1,962 citations
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TL;DR: In this article, the spin-orbit interaction in an inverted I${\mathrm{n}}_{0.53}$G${a}}{0.48}$As quantum well can be controlled by applying a gate voltage.
Abstract: We have confirmed that a spin-orbit interaction in an inverted I${\mathrm{n}}_{0.53}$G${\mathrm{a}}_{0.47}$As/I${\mathrm{n}}_{0.52}$A${\mathrm{l}}_{0.48}$As quantum well can be controlled by applying a gate voltage. This result shows that the spin-orbit interaction of a two-dimensional electron gas depends on the surface electric field. The dominant mechanism for the change in the spin-orbit interaction parameter can be attributed to the Rashba term. This inverted I${\mathrm{n}}_{0.53}$G${\mathrm{a}}_{0.47}$As/I${\mathrm{n}}_{0.52}$A${\mathrm{l}}_{0.48}$As heterostructure is one of the promising materials for the spin-polarized field effect transistor which is proposed by Datta and Das [Appl. Phys. Lett. 56, 665 (1990)].
1,801 citations
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Nippon Telegraph and Telephone1, Yokohama City University2, Keio University3, University of Tsukuba4, University of Queensland5, J. Craig Venter Institute6, National Institutes of Health7, Osaka University8, Novartis9, Boys Town10, Medical Research Council11, Scripps Research Institute12, University of Oregon13, Rockefeller University14, University of Milan15, Discovery Institute16, Harvard University17, University of Tokyo18, University of Edinburgh19, Duke University20, University of Texas Southwestern Medical Center21, Karolinska Institutet22, Cambridge University Hospitals NHS Foundation Trust23, Canberra Hospital24, Hyogo College of Medicine25, Wellcome Trust Sanger Institute26, University of California, San Diego27, University of Bonn28, Washington University in St. Louis29, Massachusetts Institute of Technology30
TL;DR: The present work, completely supported by physical clones, provides the most comprehensive survey of a mammalian transcriptome so far, and is a valuable resource for functional genomics.
Abstract: Only a small proportion of the mouse genome is transcribed into mature messenger RNA transcripts There is an international collaborative effort to identify all full-length mRNA transcripts from the mouse, and to ensure that each is represented in a physical collection of clones Here we report the manual annotation of 60,770 full-length mouse complementary DNA sequences These are clustered into 33,409 'transcriptional units', contributing 901% of a newly established mouse transcriptome database Of these transcriptional units, 4,258 are new protein-coding and 11,665 are new non-coding messages, indicating that non-coding RNA is a major component of the transcriptome 41% of all transcriptional units showed evidence of alternative splicing In protein-coding transcripts, 79% of splice variations altered the protein product Whole-transcriptome analyses resulted in the identification of 2,431 sense-antisense pairs The present work, completely supported by physical clones, provides the most comprehensive survey of a mammalian transcriptome so far, and is a valuable resource for functional genomics
1,663 citations
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TL;DR: In this paper, a review of double quantum dot studies for realizing solid state quantum bits is presented and the evolution of discrete energy levels in the magnetic field is studied, where the double-quantum dot geometry allows for an accurate determination of the intrinsic lifetime of discrete states in quantum dots.
Abstract: Electron transport experiments on two lateral quantum dots coupled in series are reviewed. An introduction to the charge stability diagram is given in terms of the electrochemical potentials of both dots. Resonant tunneling experiments show that the double dot geometry allows for an accurate determination of the intrinsic lifetime of discrete energy states in quantum dots. The evolution of discrete energy levels in magnetic field is studied. The resolution allows one to resolve avoided crossings in the spectrum of a quantum dot. With microwave spectroscopy it is possible to probe the transition from ionic bonding (for weak interdot tunnel coupling) to covalent bonding (for strong interdot tunnel coupling) in a double dot artificial molecule. This review is motivated by the relevance of double quantum dot studies for realizing solid state quantum bits.
1,627 citations
Authors
Showing all 13007 results
Name | H-index | Papers | Citations |
---|---|---|---|
Akira Yamamoto | 117 | 1999 | 74961 |
Yoshihisa Yamamoto | 108 | 811 | 42805 |
Leo P. Kouwenhoven | 98 | 373 | 44960 |
Robert Vajtai | 94 | 437 | 36002 |
Yasuhiro Tokura | 83 | 579 | 27472 |
Klara Nahrstedt | 76 | 654 | 24395 |
Stephen M. Barnett | 75 | 534 | 23899 |
Stephen H. Hughes | 73 | 498 | 20820 |
Takao Koike | 72 | 524 | 27122 |
Hisanori Shinohara | 72 | 637 | 20020 |
Peide D. Ye | 72 | 412 | 31504 |
Masaaki Tanaka | 71 | 860 | 22443 |
Koji Yamada | 71 | 810 | 21893 |
Masahito Ueda | 70 | 422 | 18412 |
Yasuhiko Arakawa | 69 | 934 | 26098 |