T
Toshihiro Kai
Researcher at University of Tokyo
Publications - 5
Citations - 265
Toshihiro Kai is an academic researcher from University of Tokyo. The author has contributed to research in topics: Antigen & Autoantibody. The author has an hindex of 5, co-authored 5 publications receiving 212 citations.
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Journal ArticleDOI
Obesity-Associated Autoantibody Production Requires AIM to Retain the Immunoglobulin M Immune Complex on Follicular Dendritic Cells
Satoko Arai,Natsumi Maehara,Yoshihiro Iwamura,Shin-ichiro Honda,Katsuhiko Nakashima,Toshihiro Kai,Masato Ogishi,Kumiko Morita,Jun Kurokawa,Mayumi Mori,Yuji Motoi,Kensuke Miyake,Nobuyuki Matsuhashi,Ken Ichi Yamamura,Osamu Ohara,Akira Shibuya,Edward K. Wakeland,Quan Zhen Li,Toru Miyazaki +18 more
TL;DR: The AIM-IgM association plays a critical role in the obesity-associated autoimmune process, and the increase of multiple IgG autoantibodies observed in obese wild-type mice was abrogated.
Journal ArticleDOI
Circulating AIM prevents hepatocellular carcinoma through complement activation
Natsumi Maehara,Satoko Arai,Mayumi Mori,Yoshihiro Iwamura,Jun Kurokawa,Toshihiro Kai,Shunsuke Kusunoki,Kaori Taniguchi,Kazutaka Ikeda,Osamu Ohara,Ken Ichi Yamamura,Toru Miyazaki +11 more
TL;DR: This work shows the potent anti-HCC effect of the circulating protein AIM, which prevented tumor development in AIM(-/-) mice, and HCC induction by diethylnitrosamine was more prominent in A IM (-/-) than wild-type mice.
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Circulating AIM as an indicator of liver damage and hepatocellular carcinoma in humans
Tomoko Yamazaki,Mayumi Mori,Satoko Arai,Ryosuke Tateishi,Masanori Abe,Mihoko Ban,Akemi Nishijima,Maki Maeda,Takeharu Asano,Toshihiro Kai,Kiyohiro Izumino,Jun Takahashi,Kayo Aoyama,Sei Harada,Toru Takebayashi,Toshiaki Gunji,Shin Ohnishi,Shinji Seto,Yukio Yoshida,Yoichi Hiasa,Kazuhiko Koike,Ken Ichi Yamamura,Ken Ichiro Inoue,Toru Miyazaki +23 more
TL;DR: It is demonstrated that a circulating protein, apoptosis inhibitor of macrophage (AIM) may meet the requirement to accurately reflect the state of liver damage and presence of HCC.
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Dietary fructose‐induced hepatocellular carcinoma development manifested in mice lacking apoptosis inhibitor of macrophage (AIM)
TL;DR: It is suggested that dietary fructose increases the risk for liver carcinogenesis and that individuals with low blood AIM levels may be susceptible to HCC under chronic fructose intake.
Journal ArticleDOI
Stabilization and Augmentation of Circulating AIM in Mice by Synthesized IgM-Fc
TL;DR: These findings reveal potent strategies to safely increase AIM levels, which could form the basis for developing novel therapies for obesity.