H
Hidetoshi Takada
Researcher at University of Tsukuba
Publications - 247
Citations - 7535
Hidetoshi Takada is an academic researcher from University of Tsukuba. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 38, co-authored 224 publications receiving 6787 citations. Previous affiliations of Hidetoshi Takada include Kyushu University & University Health Network.
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Journal ArticleDOI
Dominant-negative mutations in the DNA-binding domain of STAT3 cause hyper-IgE syndrome
Yoshiyuki Minegishi,Masako Saito,Shigeru Tsuchiya,Ikuya Tsuge,Hidetoshi Takada,Toshiro Hara,Nobuaki Kawamura,Tadashi Ariga,Srdjan Pasic,Oliver Stojkovic,Ayse Metin,Hajime Karasuyama +11 more
TL;DR: It is shown that dominant-negative mutations in the human signal transducer and activator of transcription 3 (STAT3) gene result in the classical multisystem HIES, highlighting the multiple roles played by STAT3 in humans, and underline the critical involvement of multiple cytokine pathways in the pathogenesis of HIES.
Journal ArticleDOI
Human Tyrosine Kinase 2 Deficiency Reveals Its Requisite Roles in Multiple Cytokine Signals Involved in Innate and Acquired Immunity
Yoshiyuki Minegishi,Masako Saito,Tomohiro Morio,Ken Watanabe,Kazunaga Agematsu,Shigeru Tsuchiya,Hidetoshi Takada,Toshiro Hara,Nobuaki Kawamura,Tadashi Ariga,Hideo Kaneko,Naomi Kondo,Ikuya Tsuge,Akihiro Yachie,Yukio Sakiyama,Tsutomu Iwata,Fumio Bessho,Tsutomu Oh-ishi,Kosuke Joh,Kohsuke Imai,Kazuhiro Kogawa,Miwa Shinohara,Mikiya Fujieda,Hiroshi Wakiguchi,Srdjan Pasic,Mario Abinun,Hans D. Ochs,Eleonore D. Renner,Eleonore D. Renner,Annette Jansson,Bernd H. Belohradsky,Ayse Metin,Norio Shimizu,Shuki Mizutani,Toshio Miyawaki,Shigeaki Nonoyama,Hajime Karasuyama +36 more
TL;DR: It is demonstrated that Tyk2 plays obligatory roles in multiple cytokine signals involved in innate and acquired immunity of humans, which differs substantially fromTyk2 function in mice.
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Selective predisposition to bacterial infections in IRAK-4–deficient children: IRAK-4–dependent TLRs are otherwise redundant in protective immunity
Cheng-Lung Ku,Horst von Bernuth,Horst von Bernuth,Capucine Picard,Shen-Ying Zhang,Huey Hsuan Chang,Kun Yang,Maya Chrabieh,Andrew C. Issekutz,Coleen K. Cunningham,John I. Gallin,Steven M. Holland,Chaim M. Roifman,Stephan Ehl,Joanne Smart,Mimi L.K. Tang,Franck J. Barrat,Ofer Levy,Douglas R. McDonald,Noorbibi K. Day-Good,Richard L. Miller,Hidetoshi Takada,Toshiro Hara,Sami Al-Hajjar,Abdulaziz Al-Ghonaium,David P. Speert,Damien Sanlaville,Xiaoxia Li,Frederic Geissmann,Eric Vivier,László Maródi,Ben Zion Garty,Helen Chapel,Carlos Rodríguez-Gallego,Xavier Bossuyt,Laurent Abel,Anne Puel,Jean-Laurent Casanova +37 more
TL;DR: The IRAK-4–dependent TLRs and IL-1Rs are therefore vital for childhood immunity to pyogenic bacteria, particularly Streptococcus pneumoniae, and appear to play a redundant role in protective immunity to most infections.
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Clinical Features and Outcome of Patients With IRAK-4 and MyD88 Deficiency
Capucine Picard,Capucine Picard,Horst von Bernuth,Horst von Bernuth,Horst von Bernuth,Pegah Ghandil,Pegah Ghandil,Pegah Ghandil,Maya Chrabieh,Maya Chrabieh,Ofer Levy,Peter D. Arkwright,Douglas R. McDonald,Raif S. Geha,Hidetoshi Takada,Jens C. Krause,C. Buddy Creech,Cheng-Lung Ku,Cheng-Lung Ku,Stephan Ehl,László Maródi,Saleh Al-Muhsen,Saleh Al-Muhsen,Sami Al-Hajjar,Sami Al-Hajjar,Abdulaziz Al-Ghonaium,Abdulaziz Al-Ghonaium,Noorbibi K. Day-Good,Steven M. Holland,John I. Gallin,Helen Chapel,David P. Speert,Carlos Rodríguez-Gallego,Elena Colino,Ben Zion Garty,Chaim M. Roifman,Toshiro Hara,Hideto Yoshikawa,Shigeaki Nonoyama,Joseph B. Domachowske,Andrew C. Issekutz,Mimi L.K. Tang,Joanne Smart,Simona Eva Zitnik,Cyrille Hoarau,Dinakantha S. Kumararatne,Adrian J. Thrasher,E. Graham Davies,Claire Bethune,Nicolas Sirvent,Dominique De Ricaud,Yildiz Camcioglu,Júlia Vasconcelos,Margarida Guedes,Artur Bonito Vitor,Carlos Rodrigo,Francisco Almazán,Maria Méndez,Juan I. Aróstegui,Laia Alsina,Claudia Fortuny,Janine Reichenbach,James W. Verbsky,Xavier Bossuyt,Rainer Döffinger,Laurent Abel,Laurent Abel,Anne Puel,Anne Puel,Jean-Laurent Casanova +69 more
TL;DR: IRAK-4 and MyD88 deficiencies predispose patients to recurrent life-threatening bacterial diseases, such as invasive pneumococcal disease in particular, in infancy and early childhood, with weak signs of inflammation.
Journal ArticleDOI
High Incidence of NLRP3 Somatic Mosaicism in Patients With Chronic Infantile Neurologic, Cutaneous, Articular Syndrome: Results of an International Multicenter Collaborative Study
Naoko Tanaka,Kazushi Izawa,Megumu K. Saito,Mio Sakuma,Koichi Oshima,Osamu Ohara,Ryuta Nishikomori,Takeshi Morimoto,Naotomo Kambe,Raphaela Goldbach-Mansky,Ivona Aksentijevich,Geneviève de Saint Basile,Bénédicte Neven,Marielle E. van Gijn,Joost Frenkel,Juan I. Aróstegui,Jordi Yagüe,Rosa Merino,Mercedes Ibañez,Alessandra Pontillo,Hidetoshi Takada,Tomoyuki Imagawa,Tomoki Kawai,Takahiro Yasumi,Tatsutoshi Nakahata,Toshio Heike +25 more
TL;DR: Somatic NLRP3 mosaicism is a major cause of NOMID/CINCA syndrome, and in vitro functional assays indicated that the detected somaticNLRP3 mutations had disease-causing functional effects.