다중혈관 관상동맥 환자에서 y-문합을 이용하여 양쪽 내흉동맥만을 사용한 우회술의 조기 성적

抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

[신간의 별자리x] 우리/미술, 그리고 ‘슬픔의 박물관’

Metamaterials, or engineered materials with rationally designed, subwavelength-scale building blocks, allow us to control the behavior of physical fields in optical, microwave, radio, acoustic, heat transfer, and other applications with flexibility and performance that are unattainable with naturally available materials. In turn, metasurfaces-planar, ultrathin metamaterials-extend these capabilities even further. Optical metasurfaces offer the fascinating possibility of controlling light with surface-confined, flat components. In the planar photonics concept, it is the reduced dimensionality of the optical metasurfaces that enables new physics and, therefore, leads to functionalities and applications that are distinctly different from those achievable with bulk, multilayer metamaterials. Here, we review the progress in developing optical metasurfaces that has occurred over the past few years with an eye toward the promising future directions in the field.

/pdf/planar-photonics-with-metasurfaces-1sfd62lis7.pdf

Planar Photonics with Metasurfaces

Subwavelength resolution imaging requires high numerical aperture (NA) lenses, which are bulky and expensive. Metasurfaces allow the miniaturization of conventional refractive optics into planar structures. We show that high-aspect-ratio titanium dioxide metasurfaces can be fabricated and designed as metalenses with NA = 0.8. Diffraction-limited focusing is demonstrated at wavelengths of 405, 532, and 660 nm with corresponding efficiencies of 86, 73, and 66%. The metalenses can resolve nanoscale features separated by subwavelength distances and provide magnification as high as 170×, with image qualities comparable to a state-of-the-art commercial objective. Our results firmly establish that metalenses can have widespread applications in laser-based microscopy, imaging, and spectroscopy.

Metalenses at visible wavelengths: Diffraction-limited focusing and subwavelength resolution imaging.

Tunable Metasurfaces: Kerker-Conditioned Dynamic Cryptographic Nanoprints (Advanced Optical Materials 4/2019)

Resolution of the conventional lens is limited to half the wavelength of the light source by diffraction. In the conventional optical system, evanescent waves, which carry sub-diffraction spatial information, has exponentially decaying amplitude and therefore cannot reach to the image plane. New optical materials called metamaterials have provided new ways to overcome diffraction limit in imaging by controlling the evanescent waves. Such extraordinary electromagnetic properties can be achieved and controlled through arranging nanoscale building blocks appropriately. Here, we review metamaterial-based lenses which offer the new types of imaging components and functions. Perfect lens, superlenses, hyperlenses, metalenses, flat lenses based on metasurfaces, and non-optical lenses including acoustic hyperlens are described. Not all of them offer sub-diffraction imaging, but they provide new imaging mechanisms by controlling and manipulating the path of light. The underlying physics, design principles, recent advances, major limitations and challenges for the practical applications are discussed in this review.

/pdf/metamaterials-and-imaging-4o8d8nsveo.pdf

Metamaterials and imaging.

Metamaterials are composed of nanostructures, called artificial atoms, which can give metamaterials extraordinary properties that cannot be found in natural materials. The nanostructures themselves and their arrangements determine the metamaterials’ properties. However, a conventional metamaterial has fixed properties in general, which limit their use. Thus, real-world applications of metamaterials require the development of tunability. This paper reviews studies that realized tunable and reconfigurable metamaterials that are categorized by the mechanisms that cause the change: inducing temperature changes, illuminating light, inducing mechanical deformation, and applying electromagnetic fields. We then provide the advantages and disadvantages of each mechanism and explain the results or effects of tuning. We also introduce studies that overcome the disadvantages or strengthen the advantages of each classified tunable metamaterial.

https://www.mdpi.com/2072-666X/9/11/560/pdf

Recent Advances in Tunable and Reconfigurable Metamaterials

The high refractive index of hydrogenated amorphous silicon (a-Si:H) at optical frequencies is an essential property for the efficient modulation of the phase and amplitude of light. However, substantial optical loss represented by its high extinction coefficient prevents it from being utilized widely. Here, the bonding configurations of a-Si:H are investigated, in order to manipulate the extinction coefficient and produce a material that is competitive with conventional transparent materials, such as titanium dioxide and gallium nitride. This is achieved by controlling the hydrogenation and silicon disorder by adjusting the chemical deposition conditions. The extinction coefficient of the low-loss a-Si:H reaches a minimum of 0.082 at the wavelength of 450 nm, which is lower than that of crystalline silicon (0.13). Beam-steering metasurfaces are demonstrated to validate the low-loss optical properties, reaching measured efficiencies of 42%, 62%, and 75% at the wavelengths of 450, 532, and 635 nm, respectively. Considering its compatibility with mature complementary metal-oxide-semiconductor processes, the low-loss a-Si:H will provide a platform for efficient photonic operating in the full visible regime.

Revealing Structural Disorder in Hydrogenated Amorphous Silicon for a Low-Loss Photonic Platform at Visible Frequencies.

Hyperbolic metamaterials, horizontally stacked metal and dielectric multilayer, have recently been studied as a platform to observe optical spin Hall effect. However, the large optical spin Hall effect in the horizontal hyperbolic metamaterials accompanies extremely low transmission, which obstructs its practical applications. Reducing the sample thickness to augment the transmission causes diminishment of the shift. In this letter, we demonstrate that a vertical hyperbolic metamaterial can enhance the shift by several orders of magnitude in comparison to the shift of its horizontal counterpart. Under the same conditions of material combinations and total thickness, the shift enhancement, which is incident angle-dependent, can be higher than 800-fold when the incident angle is 5 degree, and 5000-fold when the incident angle is 1 degree. As a proof of concept, we fabricate a large-scale gold nano-grating by nanoimprint lithography and measure the helicity-dependent shift by Stokes polarimetry setup, which agrees well with the simulated result. The gigantic optical spin Hall effect in a vertical hyperbolic metamaterial will enable helicity-dependent control of optical devices including filters, sensors, switches and beam splitters.

Junsuk Rho

Papers

Tunable Metasurfaces: Kerker-Conditioned Dynamic Cryptographic Nanoprints (Advanced Optical Materials 4/2019)

Metamaterials and imaging.

Recent Advances in Tunable and Reconfigurable Metamaterials

Revealing Structural Disorder in Hydrogenated Amorphous Silicon for a Low-Loss Photonic Platform at Visible Frequencies.

Observation of enhanced optical spin Hall effect in a vertical hyperbolic metamaterial