다중혈관 관상동맥 환자에서 y-문합을 이용하여 양쪽 내흉동맥만을 사용한 우회술의 조기 성적

抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

[신간의 별자리x] 우리/미술, 그리고 ‘슬픔의 박물관’

Metamaterials, or engineered materials with rationally designed, subwavelength-scale building blocks, allow us to control the behavior of physical fields in optical, microwave, radio, acoustic, heat transfer, and other applications with flexibility and performance that are unattainable with naturally available materials. In turn, metasurfaces-planar, ultrathin metamaterials-extend these capabilities even further. Optical metasurfaces offer the fascinating possibility of controlling light with surface-confined, flat components. In the planar photonics concept, it is the reduced dimensionality of the optical metasurfaces that enables new physics and, therefore, leads to functionalities and applications that are distinctly different from those achievable with bulk, multilayer metamaterials. Here, we review the progress in developing optical metasurfaces that has occurred over the past few years with an eye toward the promising future directions in the field.

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Planar Photonics with Metasurfaces

Subwavelength resolution imaging requires high numerical aperture (NA) lenses, which are bulky and expensive. Metasurfaces allow the miniaturization of conventional refractive optics into planar structures. We show that high-aspect-ratio titanium dioxide metasurfaces can be fabricated and designed as metalenses with NA = 0.8. Diffraction-limited focusing is demonstrated at wavelengths of 405, 532, and 660 nm with corresponding efficiencies of 86, 73, and 66%. The metalenses can resolve nanoscale features separated by subwavelength distances and provide magnification as high as 170×, with image qualities comparable to a state-of-the-art commercial objective. Our results firmly establish that metalenses can have widespread applications in laser-based microscopy, imaging, and spectroscopy.

Metalenses at visible wavelengths: Diffraction-limited focusing and subwavelength resolution imaging.

MAXIM: Metasurfaces-oriented electromagnetic wave simulation software with intuitive graphical user interfaces

Metasurfaces consist of artificially fabricated nanostructures and have shown potential for optical devices due to their precise control of light. Here, we demonstrate a metasurface application to improve the lateral resolution of the optical system in fluorescence microscopy based on patterned illumination. We designed and fabricated all-dielectric metasurfaces to have various encoded illumination patterns in the visible range. Super-resolution images were acquired using the designed metasurfaces in numerical simulations and in experiments. In experiments, we improved the lateral resolution to 1.71-fold of the existing system; this resolution is much finer than the diffraction limit of conventional imaging systems. We expect that our technique can provide insight into guide development of metasurfaces as patterned illumination optical devices.

Resolution enhancement of fluorescence microscopy using encoded patterns from all-dielectric metasurfaces

Miniaturization is a strong demand of modern scientific technology. However, conventional optical components based on refraction suffer from functional degradation as the device size decreases. Metasurfaces consisting of subwavelength optical antenna arrays have emerged as planar optical devices that enable many promising applications in lenses, holograms, and optical cloaks. During recent decades, metasurfaces have been developed for their specific functionalities by exploiting new materials and design algorithms. In this issue of MRS Bulletin, progress in metasurfaces is discussed to provide a comprehensive understanding of metasurfaces and their novel applications in optics and photonics.

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Metasurfaces: Subwavelength nanostructure arrays for ultrathin flat optics and photonics

By learning the optimal policy with a double deep Q-learning network, we design ultra-broadband, biomimetic, perfect absorbers with various materials, based the structure of a moths eye. All absorbers achieve over 90% average absorption from 400 to 1,600 nm. By training a DDQN with motheye structures made up of chromium, we transfer the learned knowledge to other, similar materials to quickly and efficiently find the optimal parameters from the around 1 billion possible options. The knowledge learned from previous optimisations helps the network to find the best solution for a new material in fewer steps, dramatically increasing the efficiency of finding designs with ultra-broadband absorption.

Biomimetic Ultra-Broadband Perfect Absorbers Optimised with Reinforcement Learning

Using reinforcement learning, a deep Q-network was used to design polarization-independent, perfect solar absorbers. The deep Q-network selected the geometrical properties and materials of a symmetric three-layer metamaterial made up of circular rods on top of two films. The combination of all the possible permutations gives around 500 billion possible designs. In around 30,000 steps, the deep Q-network was able to produce 1250 structures that have an integrated absorption of higher than 90% in the visible region, with a maximum of 97.6% and an integrated absorption of less than 10% in the 8–13 µm wavelength region, with a minimum of 1.37%. A statistical analysis of the distribution of materials and geometrical parameters that make up the solar absorbers is presented.

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Junsuk Rho

Papers

MAXIM: Metasurfaces-oriented electromagnetic wave simulation software with intuitive graphical user interfaces

Resolution enhancement of fluorescence microscopy using encoded patterns from all-dielectric metasurfaces

Metasurfaces: Subwavelength nanostructure arrays for ultrathin flat optics and photonics

Biomimetic Ultra-Broadband Perfect Absorbers Optimised with Reinforcement Learning

Deep Q-network to produce polarization-independent perfect solar absorbers: a statistical report