J
Justin K. Huang
Researcher at University of Texas MD Anderson Cancer Center
Publications - 16
Citations - 699
Justin K. Huang is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Cancer & Chromosome instability. The author has an hindex of 10, co-authored 14 publications receiving 489 citations. Previous affiliations of Justin K. Huang include University of California, San Diego.
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Journal ArticleDOI
Systematic Evaluation of Molecular Networks for Discovery of Disease Genes
Justin K. Huang,Daniel E. Carlin,Michael Ku Yu,Wei Zhang,Jason F. Kreisberg,Pablo Tamayo,Trey Ideker +6 more
TL;DR: This work evaluates 21 human genome-wide interaction networks for their ability to recover 446 disease gene sets identified through literature curation, gene expression profiling, or genome- wide association studies to create a parsimonious composite network with both high efficiency and performance.
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A Network of Conserved Synthetic Lethal Interactions for Exploration of Precision Cancer Therapy
Rohith Srivas,John Paul Shen,Chih Cheng Yang,Su Ming Sun,Jianfeng Li,Jianfeng Li,Andrew M. Gross,James Jensen,Katherine Licon,Ana Bojorquez-Gomez,Kristin Klepper,Justin K. Huang,Daniel Pekin,Jia L. Xu,Huwate Yeerna,Vignesh Sivaganesh,Leonie Kollenstart,Haico van Attikum,Pedro Aza-Blanc,Robert W. Sobol,Robert W. Sobol,Trey Ideker +21 more
TL;DR: A multi-species approach is used to develop a resource of synthetic lethal interactions relevant to cancer therapy and it is revealed that interaction stability across environments and shared gene function increase the likelihood of observing an interaction in human cancer cells.
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A global transcriptional network connecting noncoding mutations to changes in tumor gene expression.
Wei Zhang,Ana Bojorquez-Gomez,Daniel Ortiz Velez,Guorong Xu,Kyle S. Sanchez,John Paul Shen,Kevin Chen,Katherine Licon,Collin Melton,Katrina M. Olson,Michael Ku Yu,Justin K. Huang,Hannah Carter,Emma K. Farley,Michael Snyder,Stephanie I. Fraley,Jason F. Kreisberg,Trey Ideker +17 more
TL;DR: An integrative analysis of tumor whole genomes and matched transcriptomes finds that the effects of noncoding mutations on DAAM1, MTG2 and HYI transcription are recapitulated in multiple cancer cell lines and that increasingDAAM1 expression leads to invasive cell migration.
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Disruption of NSD1 in Head and Neck Cancer Promotes Favorable Chemotherapeutic Responses Linked to Hypomethylation.
Nam Bui,Justin K. Huang,Ana Bojorquez-Gomez,Katherine Licon,Kyle S. Sanchez,Sean Tang,Alex Beckett,Tina Wang,Wei Zhang,John Paul Shen,Jason F. Kreisberg,Trey Ideker +11 more
TL;DR: This study uses CRISPR-Cas9 to disrupt NSD1 in HNSCC cell lines and finds that this leads to substantial CpG hypomethylation and sensitivity to cisplatin, a standard chemotherapy in head and neck cancer, with a 40% to 50% decrease in the IC50 value.
Journal ArticleDOI
Genomic Landscape of Appendiceal Neoplasms
Celina S.-P. Ang,John Paul Shen,Camille J. Hardy-Abeloos,Justin K. Huang,Jeffrey S. Ross,Vincent A. Miller,Miriam T. Jacobs,Ingrid L. Chen,David Xu,Siraj M. Ali,Joel M. Baumgartner,Andrew M. Lowy,Paul T. Fanta,Trey Ideker,Sherri Z. Millis,Olivier Harismendy +15 more
TL;DR: Epithelial appendiceal cancers and goblet cell carcinoids show differences in KRAS and GNAS mutation frequencies and have mutation profiles distinct from CRC, highlighting the benefit of performing molecular profiling on rare tumors to identify prognostic and predictive biomarkers and new therapeutic targets.