H
Haico van Attikum
Researcher at Leiden University Medical Center
Publications - 91
Citations - 7459
Haico van Attikum is an academic researcher from Leiden University Medical Center. The author has contributed to research in topics: DNA repair & DNA damage. The author has an hindex of 41, co-authored 83 publications receiving 6382 citations. Previous affiliations of Haico van Attikum include Friedrich Miescher Institute for Biomedical Research & Leiden University.
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Journal ArticleDOI
Recruitment of the INO80 Complex by H2A Phosphorylation Links ATP-Dependent Chromatin Remodeling with DNA Double-Strand Break Repair
TL;DR: It is demonstrated that conversion of the DSB into ssDNA is compromised in arp8 and H2A mutants, which are both deficient for INO80 activity at the site of damage.
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Crosstalk between histone modifications during the DNA damage response.
TL;DR: How specific combinations of histone modifications affect the accumulation and function of DNA repair factors and chromatin remodeling complexes at DSBs collectively regulate DSB repair and checkpoint arrest, avoiding genomic instability and oncogenic transformation in higher eukaryotes is discussed.
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Rewiring of genetic networks in response to DNA damage
Sourav Bandyopadhyay,Monika Mehta,Dwight Kuo,Min-Kyung Sung,Ryan Chuang,Eric J. Jaehnig,Bernd Bodenmiller,Katherine Licon,Wilbert Copeland,Michael Shales,Dorothea Fiedler,Dorothea Fiedler,Janusz Dutkowski,Aude Guénolé,Haico van Attikum,Kevan M. Shokat,Kevan M. Shokat,Richard D. Kolodner,Won-Ki Huh,Ruedi Aebersold,Michael-Christopher Keogh,Nevan J. Krogan,Trey Ideker +22 more
TL;DR: Using an approach called differential epistasis mapping, widespread changes in genetic interaction are discovered among yeast kinases, phosphatases, and transcription factors as the cell responds to DNA damage, uncovering many gene functions that go undetected in static conditions.
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The Shieldin complex mediates 53BP1-dependent DNA repair
Sylvie M. Noordermeer,Sylvie M. Noordermeer,Salomé Adam,Dheva Setiaputra,Marco Barazas,Stephen J. Pettitt,Alexanda K. Ling,Michele Olivieri,Michele Olivieri,Alejandro Álvarez-Quilón,Nathalie Moatti,Michal Zimmermann,Stefano Annunziato,Dragomir B. Krastev,Feifei Song,Inger Brandsma,Jessica Frankum,Rachel Brough,Alana Sherker,Alana Sherker,Sébastien Landry,Rachel K. Szilard,Meagan Munro,Andrea McEwan,Theo Goullet de Rugy,Zhen-Yuan Lin,Traver Hart,Jason Moffat,Anne-Claude Gingras,Anne-Claude Gingras,Alberto Martin,Haico van Attikum,Jos Jonkers,Christopher J. Lord,Sven Rottenberg,Sven Rottenberg,Daniel Durocher,Daniel Durocher +37 more
TL;DR: The 53 BP1 effector complex shieldin is involved in non-homologous end-joining and immunoglobulin class switching, and acts to protect DNA ends to facilitate the repair of DNA by 53BP1, it is shown that binding of single-stranded DNA by SHLD2 is critical for shieldin function.
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Distinct roles for SWR1 and INO80 chromatin remodeling complexes at chromosomal double-strand breaks
TL;DR: These two related chromatin remodelers have distinct roles in DSB repair and checkpoint activation.