Jianfeng Li

TL;DR: Two mutually exclusive GSC subtypes, harboring distinct metabolic signaling pathways, represent intertumoral glioma heterogeneity and highlight previously unidentified roles of ALDH1A3-associated signaling that promotes aberrant proliferation of Mes HGGs and GSCs.

TL;DR: This work established a proteomics-based PAR interactome after DNA damage and identified hexokinase 1 (HK1) as a PAR binding protein, which helps explain how prolonged activation of ARTD1 triggers energy collapse and cell death, and reveals insight into the importance of nucleus-to-mitochondria communication via AR TD1 activation.

TL;DR: A multi-species approach is used to develop a resource of synthetic lethal interactions relevant to cancer therapy and it is revealed that interaction stability across environments and shared gene function increase the likelihood of observing an interaction in human cancer cells.

TL;DR: The mechanism by which 8-oxoG arises in telomeres, either by insertion of oxidized nucleotides or by direct reaction with free radicals, dictates whether telomerase is inhibited or stimulated and thereby mediates the biological outcome.

TL;DR: The first crystal structure of human AL DH1A3 complexed with NAD+ and the product all-trans retinoic acid (REA) is reported, providing information into the ALDH1As catalytic process and can be used for the structure-based design of selective inhibitors of potential medical interest.