Wei Zhang

TL;DR: A high-throughput analysis of the Otx-a enhancer, which mediates expression in the neural plate of Ciona embryos in response to fibroblast growth factor (FGF) signaling and a localized GATA determinant, provides evidence that enhancer specificity depends on submaximal recognition motifs having reduced binding affinities (“suboptimization”).

TL;DR: A detailed overview of the applications of this technology and the challenges that need to be addressed, including data preprocessing, differential gene expression analysis, alternative splicing analysis, variants detection and allele-specific expression, pathway analysis, co-expression network analysis, and applications combining various experimental procedures is presented in this article.

TL;DR: This work evaluates 21 human genome-wide interaction networks for their ability to recover 446 disease gene sets identified through literature curation, gene expression profiling, or genome- wide association studies to create a parsimonious composite network with both high efficiency and performance.

TL;DR: It is shown that enhancer syntax (the order, orientation, and spacing of transcription factor binding sites) is important for tissue-specific gene expression, and enhancers with low-affinity binding sites can mediate robust tissue specific patterns of gene expression when they are organized with optimal syntax.

TL;DR: Using an unbiased proteomic screen, mTORC2 is identified as a critical regulator of amino acid metabolism in cancer via phosphorylation of the cystine-glutamate antiporter xCT, enabling tumor cells to adapt to changing environmental conditions.