J
Justin Nussbaum
Researcher at University of Virginia
Publications - 5
Citations - 866
Justin Nussbaum is an academic researcher from University of Virginia. The author has contributed to research in topics: Ubiquitin ligase & Cytotoxic T cell. The author has an hindex of 5, co-authored 5 publications receiving 765 citations.
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Journal ArticleDOI
Prion-like behaviour and tau-dependent cytotoxicity of pyroglutamylated amyloid-β
Justin Nussbaum,Stephan Schilling,Holger Cynis,Antonia Silva,Eric Swanson,Tanaporn Wangsanut,Kaycie K. Tayler,Brian J. Wiltgen,Asa Hatami,Raik Rönicke,Klaus G. Reymann,Birgit Hutter-Paier,Anca Alexandru,Wolfgang Jagla,Sigrid Graubner,Charles G. Glabe,Hans-Ulrich Demuth,George S. Bloom +17 more
TL;DR: It is concluded that Aβ3(pE)–42 confers tau-dependent neuronal death and causes template-induced misfolding of Aβ1–42 into structurally distinct LNOs that propagate by a prion-like mechanism.
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Competing E3 Ubiquitin Ligases Govern Circadian Periodicity by Degradation of CRY in Nucleus and Cytoplasm
Seung Hee Yoo,Jennifer A. Mohawk,Sandra M. Siepka,Yongli Shan,Seong Kwon Huh,Hee Kyung Hong,Izabela Kornblum,Vivek Kumar,Nobuya Koike,Ming Xu,Justin Nussbaum,Xinran Liu,Zheng Chen,Zhijian J. Chen,Carla B. Green,Carla B. Green,Joseph S. Takahashi +16 more
TL;DR: The balance and cellular compartmentalization of competing E3 ligases for CRY determine circadian period of the clock in mammals.
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Alzheimer disease: a tale of two prions.
TL;DR: Evidence for the prion-like properties of both Aβ and tau individually are discussed, as well as the intriguing possibility that misfolded Aβ acts as a template for tau misfolding in vivo.
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Significant association of the neurexin-1 gene (NRXN1) with nicotine dependence in European- and African-American smokers
TL;DR: The neurexin-1 gene represents a strong candidate for involvement in the etiology of ND, based on findings that NRXN1 has significant association with ND in two independent samples, recent findings that it plays an important role in synaptic development, and the previous report of association.
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Significant association of glutamate receptor, ionotropic N-methyl-d-aspartate 3A (GRIN3A), with nicotine dependence in European- and African-American smokers
TL;DR: It is concluded that GRIN3A represents a strong candidate for involvement in the etiology of ND and warrants further investigation in independent samples.