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Yongli Shan
Researcher at University of Texas Southwestern Medical Center
Publications - 19
Citations - 1013
Yongli Shan is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 9, co-authored 10 publications receiving 799 citations. Previous affiliations of Yongli Shan include Chinese Academy of Sciences.
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Journal ArticleDOI
Competing E3 Ubiquitin Ligases Govern Circadian Periodicity by Degradation of CRY in Nucleus and Cytoplasm
Seung Hee Yoo,Jennifer A. Mohawk,Sandra M. Siepka,Yongli Shan,Seong Kwon Huh,Hee Kyung Hong,Izabela Kornblum,Vivek Kumar,Nobuya Koike,Ming Xu,Justin Nussbaum,Xinran Liu,Zheng Chen,Zhijian J. Chen,Carla B. Green,Carla B. Green,Joseph S. Takahashi +16 more
TL;DR: The balance and cellular compartmentalization of competing E3 ligases for CRY determine circadian period of the clock in mammals.
Journal ArticleDOI
Crystal structure of the heterodimeric CLOCK:BMAL1 transcriptional activator complex.
Nian Huang,Yogarany Chelliah,Yongli Shan,Clinton A. Taylor,Seung Hee Yoo,Carrie L. Partch,Carrie L. Partch,Carla B. Green,Hong Zhang,Joseph S. Takahashi +9 more
TL;DR: The crystal structure of a complex containing the mouse CLOCK:BMAL1 bHLH-PAS domains reveals an unusual asymmetric heterodimer with the three domains in each of the two subunits involved in dimerization interactions, resulting in three distinct protein interfaces.
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Neuromedin S-Producing Neurons Act as Essential Pacemakers in the Suprachiasmatic Nucleus to Couple Clock Neurons and Dictate Circadian Rhythms
Ivan T. Lee,Alexander S. Chang,Manabu Manandhar,Yongli Shan,Junmei Fan,Mariko Izumo,Yuichi Ikeda,Toshiyuki Motoike,Shelley Dixon,Jeffrey E. Seinfeld,Joseph S. Takahashi,Joseph S. Takahashi,Masashi Yanagisawa,Masashi Yanagisawa +13 more
TL;DR: It is shown that a subset of SCN neurons expressing the neuropeptide neuromedin S (NMS) plays an essential role in the generation of daily rhythms in behavior, and lengthening period within Nms neurons is sufficient to lengthen period of the SCN and behavioral circadian rhythms.
Journal ArticleDOI
Nudel Binds Cdc42GAP to Modulate Cdc42 Activity at the Leading Edge of Migrating Cells
Yidong Shen,Ning Li,Shuang Wu,Yizhuo Zhou,Yongli Shan,Qiangge Zhang,Chong Ding,Quan Yuan,Fukun Zhao,Rong Zeng,Xueliang Zhu +10 more
TL;DR: It is shown that Nudel, a cytoplasmic dynein regulator, competes with Cdc42 for binding CDC42GAP, a small GTPase whose activation at the leading edge by guanine nucleotide exchange factors is critical for cell migration.
Journal ArticleDOI
An evolutionary hotspot defines functional differences between CRYPTOCHROMES
Clark Rosensweig,Kimberly A. Reynolds,Peng Gao,Isara Laothamatas,Yongli Shan,Rama Ranganathan,Joseph S. Takahashi,Carla B. Green +7 more
TL;DR: The identification of an ancestral secondary cofactor-binding pocket as an interface in repressive CRYs, mediating regulation through direct interaction with CLOCK and BMAL1 is reported, suggesting that subtle sequence divergences at this site can modulate clock function.