J
Justine A. Scott
Researcher at Broad Institute
Publications - Â 3
Citations - Â 1038
Justine A. Scott is an academic researcher from Broad Institute. The author has contributed to research in topics: Genome & Data descriptor. The author has an hindex of 3, co-authored 3 publications receiving 962 citations.
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Journal ArticleDOI
Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer
Hiu Wing Cheung,Glenn S. Cowley,Barbara A. Weir,Jesse S. Boehm,Scott F. Rusin,Justine A. Scott,Alexandra East,Levi D. Ali,Patrick H. Lizotte,Terence C. Wong,Guozhi Jiang,Jessica Hsiao,Craig H. Mermel,Gad Getz,Jordi Barretina,Shuba Gopal,Pablo Tamayo,Joshua Gould,Aviad Tsherniak,Nicolas Stransky,Biao Luo,Yin Ren,Ronny Drapkin,Sangeeta N. Bhatia,Jill P. Mesirov,Levi A. Garraway,Matthew Meyerson,Eric S. Lander,David E. Root,William C. Hahn +29 more
TL;DR: Assessment of the essentiality of 11,194 genes in 102 human cancer cell lines shows that the integration of genome-scale functional and structural studies provides an efficient path to identify dependencies of specific cancer types on particular genes and pathways.
Journal ArticleDOI
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies
Glenn S. Cowley,Barbara A. Weir,Barbara A. Weir,Francisca Vazquez,Francisca Vazquez,Pablo Tamayo,Justine A. Scott,Scott F. Rusin,Alexandra East-Seletsky,Levi D. Ali,William F.J Gerath,Sarah E Pantel,Patrick H. Lizotte,Guozhi Jiang,Jessica Hsiao,Aviad Tsherniak,Elizabeth Dwinell,Simon Aoyama,Michael Okamoto,William F. Harrington,Ellen Gelfand,Thomas M Green,Mark J Tomko,Shuba Gopal,Terence C. Wong,Hubo Li,Sara Howell,Nicolas Stransky,Ted Liefeld,Dongkeun Jang,Jonathan Bistline,Barbara Hill Meyers,Scott A. Armstrong,Kenneth C. Anderson,Kimberly Stegmaier,Kimberly Stegmaier,Michael R. Reich,David Pellman,Jesse S. Boehm,Jill P. Mesirov,Todd R. Golub,David E. Root,William C. Hahn +42 more
TL;DR: This dataset facilitates the linkage of genetic dependencies with specific cellular contexts (e.g., gene mutations or cell lineage) and developed and provided a bioinformatics tool to identify linear and nonlinear correlations between these features.
Journal ArticleDOI
Erratum: Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies
Glenn S. Cowley,Barbara A. Weir,Francisca Vazquez,Pablo Tamayo,Justine A. Scott,Scott F. Rusin,Alexandra East-Seletsky,Levi D. Ali,William F.J Gerath,Sarah E Pantel,Patrick H. Lizotte,Guozhi Jiang,Jessica Hsiao,Aviad Tsherniak,Elizabeth Dwinell,Simon Aoyama,Michael Okamoto,William F. Harrington,Ellen Gelfand,Thomas M Green,Mark J Tomko,Shuba Gopal,Terence C. Wong,Hubo Li,Sara Howell,Nicolas Stransky,Ted Liefeld,Dongkeun Jang,Jonathan Bistline,Barbara Hill Meyers,Scott A. Armstrong,Kenneth C. Anderson,Kimberly Stegmaier,Michael R. Reich,David Pellman,Jesse S. Boehm,Jill P. Mesirov,Todd R. Golub,David E. Root,William C. Hahn +39 more
TL;DR: The original version of this Data Descriptor contained a typographical error in the spelling of the author Terence C. Wong, which was incorrectly given as Terrence C Wong as discussed by the authors.