T
Terence C. Wong
Researcher at Children's Institute Inc.
Publications - 14
Citations - 1673
Terence C. Wong is an academic researcher from Children's Institute Inc.. The author has contributed to research in topics: Gene & Exome sequencing. The author has an hindex of 8, co-authored 14 publications receiving 1247 citations. Previous affiliations of Terence C. Wong include Harvard University & Harvey Mudd College.
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Journal ArticleDOI
Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer
Hiu Wing Cheung,Glenn S. Cowley,Barbara A. Weir,Jesse S. Boehm,Scott F. Rusin,Justine A. Scott,Alexandra East,Levi D. Ali,Patrick H. Lizotte,Terence C. Wong,Guozhi Jiang,Jessica Hsiao,Craig H. Mermel,Gad Getz,Jordi Barretina,Shuba Gopal,Pablo Tamayo,Joshua Gould,Aviad Tsherniak,Nicolas Stransky,Biao Luo,Yin Ren,Ronny Drapkin,Sangeeta N. Bhatia,Jill P. Mesirov,Levi A. Garraway,Matthew Meyerson,Eric S. Lander,David E. Root,William C. Hahn +29 more
TL;DR: Assessment of the essentiality of 11,194 genes in 102 human cancer cell lines shows that the integration of genome-scale functional and structural studies provides an efficient path to identify dependencies of specific cancer types on particular genes and pathways.
Journal ArticleDOI
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies
Glenn S. Cowley,Barbara A. Weir,Barbara A. Weir,Francisca Vazquez,Francisca Vazquez,Pablo Tamayo,Justine A. Scott,Scott F. Rusin,Alexandra East-Seletsky,Levi D. Ali,William F.J Gerath,Sarah E Pantel,Patrick H. Lizotte,Guozhi Jiang,Jessica Hsiao,Aviad Tsherniak,Elizabeth Dwinell,Simon Aoyama,Michael Okamoto,William F. Harrington,Ellen Gelfand,Thomas M Green,Mark J Tomko,Shuba Gopal,Terence C. Wong,Hubo Li,Sara Howell,Nicolas Stransky,Ted Liefeld,Dongkeun Jang,Jonathan Bistline,Barbara Hill Meyers,Scott A. Armstrong,Kenneth C. Anderson,Kimberly Stegmaier,Kimberly Stegmaier,Michael R. Reich,David Pellman,Jesse S. Boehm,Jill P. Mesirov,Todd R. Golub,David E. Root,William C. Hahn +42 more
TL;DR: This dataset facilitates the linkage of genetic dependencies with specific cellular contexts (e.g., gene mutations or cell lineage) and developed and provided a bioinformatics tool to identify linear and nonlinear correlations between these features.
Journal ArticleDOI
Erratum: Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies
Glenn S. Cowley,Barbara A. Weir,Francisca Vazquez,Pablo Tamayo,Justine A. Scott,Scott F. Rusin,Alexandra East-Seletsky,Levi D. Ali,William F.J Gerath,Sarah E Pantel,Patrick H. Lizotte,Guozhi Jiang,Jessica Hsiao,Aviad Tsherniak,Elizabeth Dwinell,Simon Aoyama,Michael Okamoto,William F. Harrington,Ellen Gelfand,Thomas M Green,Mark J Tomko,Shuba Gopal,Terence C. Wong,Hubo Li,Sara Howell,Nicolas Stransky,Ted Liefeld,Dongkeun Jang,Jonathan Bistline,Barbara Hill Meyers,Scott A. Armstrong,Kenneth C. Anderson,Kimberly Stegmaier,Michael R. Reich,David Pellman,Jesse S. Boehm,Jill P. Mesirov,Todd R. Golub,David E. Root,William C. Hahn +39 more
TL;DR: The original version of this Data Descriptor contained a typographical error in the spelling of the author Terence C. Wong, which was incorrectly given as Terrence C Wong as discussed by the authors.
Journal ArticleDOI
A Randomized, Controlled Trial of the Analytic and Diagnostic Performance of Singleton and Trio, Rapid Genome and Exome Sequencing in Ill Infants.
Stephen F. Kingsmore,Julie A. Cakici,Julie A. Cakici,Michelle M. Clark,Mary Gaughran,Michele Feddock,Sergey Batalov,Matthew N. Bainbridge,Jeanne Carroll,Jeanne Carroll,Sara A. Caylor,Christina Clarke,Yan Ding,Katarzyna A. Ellsworth,Lauge Farnaes,Lauge Farnaes,Amber Hildreth,Amber Hildreth,Amber Hildreth,Charlotte A. Hobbs,Kiely N. James,Cyrielle Kint,Jerica Lenberg,Shareef Nahas,Lance Prince,Iris Reyes,Lisa Salz,Erica Sanford,Erica Sanford,Peter Schols,Nathaly M. Sweeney,Nathaly M. Sweeney,Mari Tokita,Narayanan Veeraraghavan,Kelly Watkins,Kristen Wigby,Kristen Wigby,Terence C. Wong,Shimul Chowdhury,Meredith S. Wright,David Dimmock,Zaira Bezares,Cinnamon S. Bloss,Joshua J.A. Braun,Carlos Diaz,Dana Mashburn,Dorjee Tamang,Daniken Orendain,Jenni Friedman,Joe Gleeson,Jaime Barea,George Chiang,Casey Cohenmeyer,Nicole G. Coufal,Marva Evans,Jose Honold,Raymond Hovey,Amy S. Kimball,Brian Lane,Crystal Le,Jennie Le,Sandra Leibel,Laurel Moyer,Patrick Mulrooney,Daeheon Oh,Paulina Ordonez,Albert Oriol,Maria Ortiz-Arechiga,Laura Puckett,Mark Speziale,Denise Suttner,Lucitia Van Der Kraan,Gail Knight,Charles Sauer,Richard S. Song,Sarah White,Audra Wise,Catherine Yamada +77 more
TL;DR: In conclusion, rapid genomic sequencing can be performed as a first-tier diagnostic test in inpatient infants and urWGS had the shortest time to result, which was important in unstable infants, and those in whom a genetic diagnosis was likely to impact immediate management.
Journal ArticleDOI
Diagnosis of genetic diseases in seriously ill children by rapid whole-genome sequencing and automated phenotyping and interpretation
Michelle M. Clark,Amber Hildreth,Amber Hildreth,Amber Hildreth,Sergey Batalov,Yan Ding,Shimul Chowdhury,Kelly Watkins,Katarzyna A. Ellsworth,Brandon Camp,Cyrielle Kint,Calum Yacoubian,Lauge Farnaes,Lauge Farnaes,Matthew N. Bainbridge,Curtis Beebe,Joshua J.A. Braun,Margaret Bray,Jeanne Carroll,Jeanne Carroll,Julie A. Cakici,Sara A. Caylor,Christina Clarke,Mitchell Creed,Jennifer Friedman,Jennifer Friedman,Alison Frith,Richard Gain,Mary Gaughran,Shauna George,Sheldon Gilmer,Joseph G. Gleeson,Joseph G. Gleeson,Jeremy Gore,Haiying Li Grunenwald,Raymond Hovey,Marie L. Janes,Kejia Lin,Paul D. McDonagh,Kyle McBride,Patrick Mulrooney,Shareef Nahas,Daeheon Oh,Albert Oriol,Laura Puckett,Zia Rady,Martin G. Reese,Julie Ryu,Julie Ryu,Lisa Salz,Erica Sanford,Erica Sanford,Lawrence Stewart,Nathaly M. Sweeney,Nathaly M. Sweeney,Mari Tokita,Luca Van Der Kraan,Sarah White,Kristen Wigby,Kristen Wigby,Brett Williams,Terence C. Wong,Meredith S. Wright,Catherine Yamada,Peter Schols,John Reynders,Kevin Hall,David Dimmock,Narayanan Veeraraghavan,Thomas Defay,Stephen F. Kingsmore +70 more
TL;DR: A platform for population-scale, provisional diagnosis of genetic diseases with automated phenotyping and interpretation and could aid clinicians to expedite an accurate genetic disease diagnosis, potentially hastening lifesaving changes to patient care.