Y
Yin Ren
Researcher at University of California, San Diego
Publications - 37
Citations - 1738
Yin Ren is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Hearing loss & Medicine. The author has an hindex of 13, co-authored 32 publications receiving 1494 citations. Previous affiliations of Yin Ren include Harvard University & Massachusetts Eye and Ear Infirmary.
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Journal ArticleDOI
Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer
Hiu Wing Cheung,Glenn S. Cowley,Barbara A. Weir,Jesse S. Boehm,Scott F. Rusin,Justine A. Scott,Alexandra East,Levi D. Ali,Patrick H. Lizotte,Terence C. Wong,Guozhi Jiang,Jessica Hsiao,Craig H. Mermel,Gad Getz,Jordi Barretina,Shuba Gopal,Pablo Tamayo,Joshua Gould,Aviad Tsherniak,Nicolas Stransky,Biao Luo,Yin Ren,Ronny Drapkin,Sangeeta N. Bhatia,Jill P. Mesirov,Levi A. Garraway,Matthew Meyerson,Eric S. Lander,David E. Root,William C. Hahn +29 more
TL;DR: Assessment of the essentiality of 11,194 genes in 102 human cancer cell lines shows that the integration of genome-scale functional and structural studies provides an efficient path to identify dependencies of specific cancer types on particular genes and pathways.
Journal ArticleDOI
Intra-tumor Genetic Heterogeneity and Mortality in Head and Neck Cancer: Analysis of Data from The Cancer Genome Atlas
Edmund A. Mroz,Aaron M. Tward,Aaron M. Tward,Rebecca J. Hammon,Yin Ren,James W. Rocco,James W. Rocco,James W. Rocco +7 more
TL;DR: This study is the first to combine data from hundreds of patients, treated at multiple institutions, to document a relation between intra-tumor heterogeneity and overall survival in any type of cancer.
Journal ArticleDOI
Cancer Vulnerabilities Unveiled by Genomic Loss
Deepak Nijhawan,Travis I. Zack,Travis I. Zack,Yin Ren,Matthew R. Strickland,Rebecca Lamothe,Steven E. Schumacher,Steven E. Schumacher,Aviad Tsherniak,Henrike C. Besche,Joseph Rosenbluh,Joseph Rosenbluh,Joseph Rosenbluh,Shyemaa Shehata,Glenn S. Cowley,Barbara A. Weir,Alfred L. Goldberg,Jill P. Mesirov,David E. Root,Sangeeta N. Bhatia,Rameen Beroukhim,Rameen Beroukhim,Rameen Beroukhim,William C. Hahn,William C. Hahn,William C. Hahn +25 more
TL;DR: In this article, the authors performed integrated analyses of genome-wide copy number and RNAi profiles and identified 56 genes for which gene suppression specifically inhibited the proliferation of cells harboring partial copy number loss of that gene.
Journal ArticleDOI
Targeted Tumor-Penetrating siRNA Nanocomplexes for Credentialing the Ovarian Cancer Oncogene ID4
Yin Ren,Hiu Wing Cheung,Hiu Wing Cheung,Geoffrey von Maltzhan,Amit Agrawal,Glenn S. Cowley,Barbara A. Weir,Jesse S. Boehm,Pablo Tamayo,Alison M. Karst,Joyce F. Liu,Michelle S. Hirsch,Jill P. Mesirov,Ronny Drapkin,Ronny Drapkin,David E. Root,Justin H. Lo,Valentina Fogal,Erkki Ruoslahti,William C. Hahn,Sangeeta N. Bhatia +20 more
TL;DR: A platform for the discovery and initial validation of cancer targets, composed of a systematic effort to identify amplified and essential genes in human cancer cell lines and tumors partnered with a novel modular delivery technology.
Journal ArticleDOI
In vivo tumor cell targeting with "Click" nanoparticles
Geoffrey von Maltzahn,Yin Ren,Ji-Ho Park,Dal-Hee Min,Venkata Ramana Kotamraju,Jayanthi Jayakumar,Valentina Fogal,Michael J. Sailor,Erkki Ruoslahti,Sangeeta N. Bhatia +9 more
TL;DR: "click" chemistry allows cyclic LyP-1 targeting peptides to be specifically linked to azido-nanoparticles and to direct their binding to p32-expressing tumor cells in vitro and should expedite the progression from ligand discovery to in vivo evaluation and diversify approaches toward multifunctional nanoparticle development.