Guozhi Jiang

TL;DR: It is found that the number of CRISPR/Cas9-induced DNA breaks dictates a gene-independent antiproliferative response in cells, which has practical implications for using CRISpr/cas9 to interrogate cancer gene function and illustrate that cancer cells are highly sensitive to site-specific DNA damage, which may provide a path to novel therapeutic strategies.

TL;DR: Assessment of the essentiality of 11,194 genes in 102 human cancer cell lines shows that the integration of genome-scale functional and structural studies provides an efficient path to identify dependencies of specific cancer types on particular genes and pathways.

TL;DR: This dataset facilitates the linkage of genetic dependencies with specific cellular contexts (e.g., gene mutations or cell lineage) and developed and provided a bioinformatics tool to identify linear and nonlinear correlations between these features.

TL;DR: The original version of this Data Descriptor contained a typographical error in the spelling of the author Terence C. Wong, which was incorrectly given as Terrence C Wong as discussed by the authors.

TL;DR: It is demonstrated that MYCN upregulates EZH2, leading to inactivation of a tumor suppressor program in neuroblastoma, and support testing EZh2 inhibitors in patients with MYCN-amplified neuroblastomas.