Justyna Popiół

TL;DR: Cinnamic acid derivatives, which is currently indexed as a skin‐conditioning cosmetics ingredient, has been widely tested in vitro and in vivo as a new drug candidate for the treatment of hyperpigmentation and may become new cosmetic ingredients in the future.

TL;DR: Issues of compound metabolic stability will be discussed, with special emphasis on its significance, in vitro metabolic stability testing, dilemmas regarding in vitro-in vivo extrapolation of the results and some aspects relating to different preclinical species used in in vivo metabolic stability assessment of compounds.

TL;DR: A review of melanogenesis inhibitors can be found in this paper, with a focus on utilization of various models for evaluation of mechanisms of action of tested compounds, and the potential limitations of the methods are also discussed.

TL;DR: In the search for new organic UV filters, a series consisting of 5-benzylidene and 5-(3-phenylprop-2-en-1-ylidenes)imidazolidine-2,4-dione (hydantoin) derivatives was designed and synthesized and shown to be non-cytotoxic at concentrations up to 50 µM when tested on three types of human skin cells and possess no estrogenic activity.

TL;DR: In this article, a series of N'-phenyl- or N'-benzylbutanamide and N'-arylidenebutanehydrazide derivatives of 8-aminopurine-2,6-dione (27-43) were characterized as prominent pan-PDE inhibitors.