Jutta Lamlé

TL;DR: A central role is established for Nrf2(-/-) in the protection against ethanol-induced liver injury, as shown by an increased tumor necrosis factor-alpha secretion and activation of the interleukin-6/Stat-3 pathway, which lead to a vicious cycle of accumulating hepatocellular damage, ultimately leading to liver failure and death of NRF2 (-/-) mice.

TL;DR: Pharmacological intervention targeting miR‐221 may be therapeutically beneficial in liver failure by preventing apoptosis and by inducing liver regeneration, and accelerates hepatocyte proliferation in vivo.

TL;DR: Evidence is provided that mTOR inhibition has a substantial effect on sequential carcinogenesis and may offer an effective strategy to delay liver tumor development in patients at risk.

TL;DR: The data establish a central role for Nrf2 in the protection against Faa‐induced liver injury; the NRF2 regulated cellular defense not only prevents acute Faa•induced liver failure but also delays hepatocarcinogenesis in HT1.

TL;DR: The electrogenic Na/HCO3 cotransporter pNBC1 is an important base extruder during stimulation of acid secretion, and its absence or inhibition leads to a significant reduction in maximal acid secretory rates.