K
K. Barry Sharpless
Researcher at Scripps Research Institute
Publications - 417
Citations - 67722
K. Barry Sharpless is an academic researcher from Scripps Research Institute. The author has contributed to research in topics: Dihydroxylation & Catalysis. The author has an hindex of 101, co-authored 410 publications receiving 63322 citations. Previous affiliations of K. Barry Sharpless include University of Montana & University of Hong Kong.
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Regioselective azide opening of 2,3-epoxy alcohols by [Ti(O-i-Pr)2(N3)2]: synthesis of .alpha.-amino acids
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Synthesis of dioxobis(tert-alkylimido)osmium(VIII) and oxotris(tert-alkylimido)osmium(VIII) complexes. Stereospecific vicinal diamination of olefins
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A simple and efficient method for epoxidation of terminal alkenes
TL;DR: The use of a catalytic amount of 3-cyanopyridine in the catalytic catalysts for terminal alkenes with aqueous hydrogen peroxide resulted in the formation of many functionalized epoxides in high yields.
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Efficient Synthesis of 2-Substituted-1,2,3-triazoles
TL;DR: In this three-component reaction, alkynes undergo a copper(I)-catalyzed cycloaddition with sodium azide and formaldehyde to yield 2-hydroxymethyl-2 H-1,2,3-triazoles, which are useful intermediates that can be readily converted to polyfunctional molecules.
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In situ click chemistry: a powerful means for lead discovery
TL;DR: The kinetically controlled TGS approach, termed in situ click chemistry, is discussed in this article and has the potential to emerge as a reliable lead discovery method.